ArticleThe Journal of cell biology2005
A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis.bioRxiv : the preprint server for biology · 2026Article
- Structure and function of the keratin 17 tail domain associated with keratin intermediate filament organization.European journal of cell biology · 2025Article
- MCPIP3/Regnase-3 binds 14-3-3 proteins and contributes to the regulation of the cell cycle in human immortalized keratinocytes.Scientific reports · 2025Article
- Keratinous bioresources: their generation, microbial degradation, and value enhancement for biotechnological applications.World journal of microbiology & biotechnology · 2025Review
- Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings.Current issues in molecular biology · 2024Review
- Review
- Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain.International journal of molecular sciences · 2020Article
- Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly.Structure (London, England : 1993) · 2020Article
- Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.Human molecular genetics · 2019Article
- Human keratin 1/10-1B tetramer structures reveal a knob-pocket mechanism in intermediate filament assembly.The EMBO journal · 2019Article
- Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16.Nature communications · 2017Article
- The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease.The Journal of investigative dermatology · 2017Article
- Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery.Biomacromolecules · 2016Article
- PEG-Immobilized Keratin for Protein Drug Sequestration and pH-Mediated Delivery.Journal of drug delivery · 2016Article
- Alkylation of human hair keratin for tunable hydrogel erosion and drug delivery in tissue engineering applications.Acta biomaterialia · 2015Article
- Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2.PloS one · 2015Article
- Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.The Journal of biological chemistry · 2014Article
- One-step purification of twin-strep-tagged proteins and their complexes on strep-tactin resin cross-linked with bis(sulfosuccinimidyl) suberate (BS3).Journal of visualized experiments : JoVE · 2014Article
- Keratin intracellular concentration revisited: implications for keratin function in surface epithelia.The Journal of investigative dermatology · 2013Article
- Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Intermediate filaments (IFs) are fibrous polymers encoded by a large family of differentially expressed genes that provide crucial structural support in the cytoplasm and nucleus in higher eukaryotes. The mechanisms involved in bringing together approximately 16 elongated coiled-coil dimers to form an IF are poorly defined. Available evidence suggests that tetramer subunits play a key role during IF assembly and regulation. Through molecular modeling and site-directed mutagenesis, we document a hitherto unnoticed hydrophobic stripe exposed at the surface of coiled-coil keratin heterodimers that contributes to the extraordinary stability of heterotetramers. The inability of K16 to form urea-stable tetramers in vitro correlates with an increase in its turnover rate in vivo. The data presented support a specific conformation for the assembly competent IF tetramer, provide a molecular basis for their differential stability in vitro, and point to the physiological relevance associated with this property in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.