ArticleJournal of virology2005
The nuclear shuttle protein of Tomato leaf curl New Delhi virus is a pathogenicity determinant.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 96 citations in OpenAlex.
- Molecular Dissection of Symptom Determinants in Tomato Leaf Curl New Delhi Virus in Zucchini Through Mechanical Transmission.Viruses · 2025Article
- Identification of pathogenicity determinants in ToLCNDV and their RNAi-based knockdown for disease management inFrontiers in microbiology · 2024Article
- Transcriptional Analysis of the Differences between ToLCNDV-India and ToLCNDV-ES Leading to Contrary Symptom Development in Cucumber.International journal of molecular sciences · 2023Article
- Limited role of recombination in the global diversification of begomovirus DNA-B proteins.Virus research · 2023Article
- Coat protein is responsible for tomato leaf curl New Delhi virus pathogenicity in tomato.Frontiers in plant science · 2023Article
- FKBP-type peptidyl-prolyl cis-trans isomerase interacts with the movement protein of tomato leaf curl New Delhi virus and impacts viral replication in Nicotiana benthamiana.Molecular plant pathology · 2022Article
- Insights into the multifunctional roles of geminivirus-encoded proteins in pathogenesis.Archives of virology · 2022Review
- Synergy between an emerging monopartite begomovirus and a DNA-B component.Scientific reports · 2022Article
- Emergence of Asian endemic begomoviruses as a pandemic threat.Frontiers in plant science · 2022Review
- Molecular characterization and infectivity analysis of tomato leaf curl New Delhi virus isolates infecting potato.3 Biotech · 2021Article
- Weed-infecting viruses in a tropical agroecosystem present different threats to crops and evolutionary histories.PloS one · 2021Article
- A single amino acid substitution in the movement protein enables the mechanical transmission of a geminivirus.Molecular plant pathology · 2020Article
- Contribution of Tomato torrado virus Vp26 coat protein subunit to systemic necrosis induction and virus infectivity in Solanum lycopersicum.Virology journal · 2019Article
- AV2 protein of tomato leaf curl Palampur virus promotes systemic necrosis in Nicotiana benthamiana and interacts with host Catalase2.Scientific reports · 2018Article
- Tomato Leaf Curl New Delhi Virus: An Emerging Virus Complex Threatening Vegetable and Fiber Crops.Viruses · 2017Review
- Tomato leaf curl New Delhi virus: a widespread bipartite begomovirus in the territory of monopartite begomoviruses.Molecular plant pathology · 2017Review
- The six Tomato yellow leaf curl virus genes expressed individually in tomato induce different levels of plant stress response attenuation.Cell stress & chaperones · 2017Article
- Maintenance of Cotton Leaf Curl Multan Betasatellite byFrontiers in plant science · 2017Article
- Natural Occurrence of Tomato leaf curl New Delhi virus in Iranian Cucurbit Crops.The plant pathology journal · 2016Article
- Dominant resistance against plant viruses.Frontiers in plant science · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the movement protein (MP) and nuclear shuttle protein (NSP) in the pathogenicity of Tomato leaf curl New Delhi virus (ToLCNDV), a bipartite begomovirus, was studied. Both genes were expressed in Nicotiana benthamiana, Nicotiana tabacum, and Lycopersicon esculentum plants with the Potato virus X (PVX) expression vector or by stable transformation of gene constructs under the control of the 35S promoter in N. tabacum. No phenotypic changes were observed in any of the three species when the MP was expressed from the PVX vector or constitutively expressed in transgenic plants. Expression of the ToLCNDV NSP from the PVX vector in N. benthamiana resulted in leaf curling that is typical of the disease symptoms caused by ToLCNDV in this species. Expression of NSP from PVX in N. tabacum and L. esculentum resulted in a hypersensitive response (HR), demonstrating that the ToLCVDV NSP is a target of host defense responses in these hosts. The NSP, when expressed as a transgene under the control of the 35S promoter, resulted in necrotic lesions in expanded leaves that initiated from a point and then spread across the leaf. The necrotic response was systemic in all the transgenic plants. Deletion of 100 amino acids from the C terminus did not compromise the HR response, suggesting that this region has no role in HR. Deletion of 60 or 100 amino acids from the N terminus of NSP abolished the HR response, suggesting that these sequences are required for the HR response. These findings demonstrate that the ToLCNDV NSP is a pathogenicity determinant as well as a target of host defense responses.
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