ArticleJournal of virology2005
Tetraspanin CD81 provides a costimulatory signal resulting in increased human immunodeficiency virus type 1 gene expression in primary CD4+ T lymphocytes through NF-kappaB, NFAT, and AP-1 transduction pathways.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Exosomal nanocarriers of immune fate: molecular insights into cancer immunity, pathogen defense, and emerging immunotherapies.Clinical and experimental immunology · 2026Review
- Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review).Molecular medicine reports · 2024Review
- Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication.Viruses · 2024Article
- Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome.Viruses · 2020Review
- A Mechanism of Resistance to Antibody-Targeted Immune Attack.Cancer immunology research · 2019Article
- Tetraspanin 1 inhibits TNFα-induced apoptosis via NF-κB signaling pathway in alveolar epithelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Article
- Review
- CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- JNK1 Derived from Orange-Spotted Grouper, Epinephelus coioides, Involving in the Evasion and Infection of Singapore Grouper Iridovirus (SGIV).Frontiers in microbiology · 2016Article
- Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent upregulation of TNF-α and IL-6.FEBS letters · 2014Article
- A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication.PloS one · 2012Article
- Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement.PloS one · 2011Article
- JNK1 is required for lentivirus entry and gene transfer.Journal of virology · 2011Article
- Tetraspanin CD151 regulates growth of mammary epithelial cells in three-dimensional extracellular matrix: implication for mammary ductal carcinoma in situ.Cancer research · 2010Article
- Novel function of CD81 in controlling hepatitis C virus replication.Journal of virology · 2010Article
- Tetraspanins regulate cell-to-cell transmission of HIV-1.Retrovirology · 2009Article
- The roles of tetraspanins in HIV-1 replication.Current topics in microbiology and immunology · 2009Review
- Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2009Review
- Altered expression of the tetraspanin CD81 on B and T lymphocytes during HIV-1 infection.Clinical and experimental immunology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tetraspanin superfamily member CD81 has been shown to form microdomains in the plasma membrane and to participate in the recruitment of numerous adhesion molecules, receptors, and signaling proteins in the central zone of the immune synapse. Beside its structural role, CD81 also delivers a cosignal for T cells to trigger cytokine production and cellular proliferation, thus suggesting a key role in some fundamental biological functions. It has been shown that signaling events initiated through the T-cell receptor (TCR)/CD3 complex and the coactivator CD28 positively affect human immunodeficiency virus type 1 (HIV-1) gene expression, but no study had investigated the putative costimulatory activity of CD81 on HIV-1 transcriptional activity. We observed that CD81 engagement potentiates TCR/CD3-mediated signaling, resulting in an enhancement of HIV-1 transcription and de novo virus production in both established Jurkat cells and primary CD4+ T lymphocytes at a magnitude that approximates that with CD28. These observations were made by using transiently transfected plasmids (i.e., nonintegrated viral DNA) and fully competent viruses (i.e., stably integrated provirus). Moreover, the CD81-mediated enhancement of HIV-1 gene expression is linked with increased nuclear translocation of transcription factors known to positively regulate virus transcription, i.e., NF-kappaB, NFAT, and AP-1. These findings suggest that engagement of CD81 decreases the signaling threshold required to initiate TCR/CD3-mediated induction of integrated HIV-1 proviral DNA in primary CD4+ T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.