ArticleJournal of virology2005
Parallel human immunodeficiency virus type 1-specific CD8+ T-lymphocyte responses in blood and mucosa during chronic infection.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 60 citations in OpenAlex.
- Differential blood and mucosal immune responses against an HIV-1 vaccine administered via inguinal or deltoid injection.PloS one · 2014Trial
- HIV-1 Nef sequence and functional compartmentalization in the gut is not due to differential cytotoxic T lymphocyte selective pressure.PloS one · 2013Trial
- Trial
- Tissue-resident immune cells: from defining characteristics to roles in diseases.Signal transduction and targeted therapy · 2025Review
- Persistent memory despite rapid contraction of circulating T Cell responses to SARS-CoV-2 mRNA vaccination.Frontiers in immunology · 2023Article
- Dominant CD8Frontiers in immunology · 2022Article
- Elevated Numbers of HIV-Specific Poly-Functional CD8Frontiers in immunology · 2021Article
- HIV-1 elite controllers: an immunovirological review and clinical perspectives.Journal of virus eradication · 2019Article
- Tissue issues: mucosal T-cell responses in HIV-1 infection.Current opinion in HIV and AIDS · 2019Review
- Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond.Current immunology reviews · 2019Article
- CD8Viral immunology · 2018Article
- Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones.Journal of virology · 2018Article
- HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth.Journal of virology · 2017Article
- Supranormal thymic output up to 2 decades after HIV-1 infection.AIDS (London, England) · 2016Article
- Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand.PloS one · 2015Article
- T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols.PloS one · 2015Article
- HIV-specific T-cell responses detected in the genital tract of chronically HIV-infected women are largely monofunctional.Immunology · 2013Article
- Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection.Mucosal immunology · 2013Article
- Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load.Frontiers in immunology · 2013Article
- Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.Journal of virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Gut-associated lymphoid tissue is the major reservoir of lymphocytes and human immunodeficiency virus type 1 (HIV-1) replication in vivo, yet little is known about HIV-1-specific CD8+ T-lymphocyte (CTL) responses in this compartment. Here we assessed the breadth and magnitude of HIV-1-specific CTL in the peripheral blood and sigmoid colon mucosa of infected subjects not on antiretroviral therapy by enzyme-linked immunospot analysis with 53 peptide pools spanning all viral proteins. Comparisons of blood and mucosal CTL revealed that the magnitude of pool-specific responses is correlated within each individual (mean r2 = 0.82 +/- 0.04) and across all individuals (r2 = 0.75; P < 0.001). Overall, 85.1% of screened peptide pools yielded concordant negative or positive results between compartments. CTL targeting was also closely related between blood and mucosa, with Nef being the most highly targeted (mean of 2.4 spot-forming cells [SFC[/10(6) CD8+ T lymphocytes/amino acid [SFC/CD8/aa]), followed by Gag (1.5 SFC/CD8/aa). Finally, comparisons of peptide pool responses seen in both blood and mucosa (concordant positives) versus those seen only in one but not the other (discordant positives) showed that most discordant results were likely an artifact of responses being near the limit of detection. Overall, these results indicate that HIV-1-specific CTL responses in the blood mirror those seen in the mucosal compartment in natural chronic infection. For protective or immunotherapeutic vaccination, it will be important to determine whether immunity is elicited in the mucosa, which is a key site of initial infection and subsequent HIV-1 replication in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.