ArticleNucleic acids research2005
Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Efficient GBA1 editing via HDR with ssODNs by outcompeting pseudogene-mediated gene conversion upon CRISPR/Cas9 cleavage.Frontiers in genome editing · 2025Article
- Analyzing Homologous Recombination Using Antibiotic Marker Substrates in Mammalian Cells.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving.Radiation research · 2017Article
- Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication.eLife · 2017Article
- Recurrent Gene Duplication Leads to Diverse Repertoires of Centromeric Histones in Drosophila Species.Molecular biology and evolution · 2017Article
- Evidence of extensive non-allelic gene conversion among LTR elements in the human genome.Scientific reports · 2016Article
- Interlocus gene conversion explains at least 2.7% of single nucleotide variants in human segmental duplications.BMC genomics · 2015Article
- Article
- Rapid and accurate large-scale genotyping of duplicated genes and discovery of interlocus gene conversions.Nature methods · 2013Article
- Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis.Genome biology and evolution · 2013Article
- Article
- Article
- Recombination-associated sequence homogenization of neighboring Alu elements: signature of nonallelic gene conversion.Molecular biology and evolution · 2010Article
- Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae.PloS one · 2010Article
- Analysis of repair mechanism choice during homologous recombination.Nucleic acids research · 2009Article
- Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences.Nucleic acids research · 2008Article
- Processing of triplex-directed psoralen DNA interstrand crosslinks by recombination mechanisms.Nucleic acids research · 2008Article
- Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Homologous recombination (HR) repairs DNA double-strand breaks and maintains genome stability. HR between linked, direct repeats can occur by gene conversion without an associated crossover that maintains the gross repeat structure. Alternatively, direct repeat HR can occur by gene conversion with a crossover, or by single-strand annealing (SSA), both of which delete one repeat and the sequences between the repeats. Prior studies of different repeat structures in yeast and mammalian cells revealed disparate conversion:deletion ratios. Here, we show that a key factor controlling this ratio is the distance between the repeats, with conversion frequency increasing linearly with the distances from 850 to 3800 bp. Deletions are thought to arise primarily by SSA, which involves extensive end-processing to reveal complementary single-strands in each repeat. The results can be explained by a model in which strand-invasion leading to gene conversion competes more effectively with SSA as more extensive end-processing is required for SSA. We hypothesized that a transcription unit between repeats would inhibit end-processing and SSA, thereby increasing the fraction of conversions. However, conversion frequencies were identical for direct repeats separated by 3800 bp of transcriptionally silent or active DNA, indicating that end-processing and SSA are not affected by transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.