ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery1992
Effects of congenital hydrocephalus on serotonergic input and barrel cytoarchitecture in the developing somatosensory cortex of rats.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 citing papers in PubMed, 19 citations in OpenAlex.
- Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network.Current medicinal chemistry · 2015Review
- Monoamine neurotransmitters and their metabolites in the mature rabbit brain following induction of hydrocephalus.Neurochemical research · 1998Article
- Neuropathological changes caused by hydrocephalus.Acta neuropathologica · 1993Review
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3 authors at 1 institution in 1 country.
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Abstract
The effects of progressive ventricular dilation on the development of the somatosensory cortex (SmI) were studied in congenital hydrocephalic rats, with regard to early serotonergic innervation and formation of functional cellular columns. In hydrocephalic rats, the time course, immunoreactivity, and patterns of formation and synaptogenesis of serotonin immunoreactive (5-HT-IR) terminal aggregations, which characterize the development of the SmI, were preserved. After disappearance of 5-HT-IR terminals, characteristic barrel cytoarchitecture formed normally at the site where 5-HT-IR terminal aggregations had been present. With the progression of hydrocephalus, the cerebral cortex became extremely thin and its total surface area was greatly increased, while barrels were preserved and their areas did not enlarge. These findings suggest that the basic development and the fundamental cytoarchitecture of the cortex are resistant to adverse effects of hydrocephalus.
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