ArticleNeurosurgical review2005
Surgical removal of growth hormone-secreting pituitary adenomas with intensive microsurgical pseudocapsule resection results in complete remission of acromegaly.
Article in Neurosurgical review, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Comparison of outcomes between intracapsular resection and pseudocapsule-based extracapsular resection for pituitary adenoma: a systematic review and meta-analysis.BMC neurology · 2022Pooled it
- Surgery induced hypopituitarism in acromegalic patients: a systematic review and meta-analysis of the results.Pituitary · 2015Pooled it
- Endoscopic endonasal transcavernous surgery for knosp grade 3-4 growth hormone-secreting pituitary neuroendocrine tumors: surgical outcomes and predictors of biochemical remission.Neurosurgical review · 2026Article
- Pregnancy and delivery after surgical remission in women with prolactinomas desiring pregnancy: Refining surgical indications.Pituitary · 2026Article
- Rapid intraoperative boundary diagnosis of somatotroph pituitary neuroendocrine tumors using real-time PCR.Acta neuropathologica communications · 2026Article
- Normal Pituitary Gland Showing an Intratumoral Septal Structure in a Nonfunctioning Pituitary Neuroendocrine Tumor: Illustrative Case.NMC case report journal · 2025Article
- Endoscopic endonasal surgery for non-invasive pituitary neuroendocrinology tumors with incomplete pseudocapsule.Frontiers in neurology · 2023Article
- Extra-Pseudocapsular Transsphenoidal Surgery for Microprolactinoma in Women.Journal of clinical medicine · 2022Article
- Pseudocapsule and pseudocapsule-based extracapsular resection in pituitary neuroendocrine tumors.Frontiers in endocrinology · 2022Review
- Development and Validation of a Prognostic Model for Post-Operative Recurrence of Pituitary Adenomas.Frontiers in oncology · 2022Article
- Effectiveness of the intraoperative magnetic resonance imaging during endoscopic endonasal approach for acromegaly.Pituitary · 2021Article
- Metachronous Double Pituitary Adenoma with Altered Transcriptional Factor Profile: A Case Report and Literature Review.NMC case report journal · 2021Article
- Pseudocapsule-Based Resection for Pituitary AdenomasFrontiers in oncology · 2021Article
- Peel-off resection of the pituitary gland for functional pituitary adenomas: pathological significance and impact on pituitary function.Pituitary · 2019Article
- Extracapsular en bloc resection in pituitary adenoma surgery.Pituitary · 2015Article
- Surgical management of Cushing's disease.Pituitary · 2015Review
- Contemporary neurosurgical techniques for pituitary tumor resection.Journal of neuro-oncology · 2014Review
- A novel simple real-time electrooculographic monitoring system during transsphenoidal surgeries to prevent postoperative extraocular motor nerve dysfunction.Neurosurgical review · 2013Article
- The pseudocapsule surrounding a pituitary adenoma and its clinical significance.Journal of neuro-oncology · 2011Review
- Novel flexible forceps for endoscopic transsphenoidal resection of pituitary tumors: technical report.Neurosurgical review · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although some investigators recommended surgical removal of the borders between pituitary adenoma and the surrounding normal pituitary gland, there is so far little documentation of how intensive dissection of the border zone affects the actual clinical remission rate of pituitary adenomas. We investigated the precise histological characteristics of the boundary, using surgical specimens from patients who underwent intensive resection of "microsurgical pseudocapsule" of growth hormone (GH)-secreting pituitary adenomas. Furthermore, we compared the remission rate of acromegaly between subjects with (Group 1) and without (Group 2) intensive resection of microsurgical pseudocapsule in order to correlate the histological complete resection and endocrinological remission. Histologically, most adenomas were in direct contact with normal pituitary gland that formed an increased fibrous component facing the adenoma, without a true histological pseudocapsule. It was impossible to dissect the tumor at exactly the tumor--normal pituitary interface for the whole extent of the pituitary adenoma during surgery, and complete removal of the tumor inevitably included a portion of normal tissue (microsurgical pseudocapsule). The biochemical remission rate was significantly higher in Group 1 than in Group 2 (90.0 vs 61.1%), and Group 1 showed no additional postoperative pituitary hypofunction. The present results suggested that intensive resection of the microsurgical pseudocapsule is essential to accomplish histological and endocrinological total resection of the GH-secreting pituitary adenomas for remission of acromegaly.
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