Trial reportEuropean journal of applied physiology2005
Living high-training low altitude training: effects on mucosal immunity.
Trial report in European journal of applied physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- Living high-training low: effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers.European journal of applied physiology · 2006Trial
- [Oral homeostasis imbalance under hypoxia].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Review
- High-altitude immune remodeling in children withFrontiers in immunology · 2025Article
- Effects of hypoxia/hyperoxia exposure on immune function - results from a spacecraft-relevant hypobaric chamber study.Frontiers in physiology · 2025Article
- Differences in stress response between two altitudes assessed by salivary cortisol levels within circadian rhythms in long-distance runners.Scientific reports · 2022Article
- Chronic Exposure to Normobaric Hypoxia Increases Testosterone Levels and Testosterone/Cortisol Ratio in Cyclists.International journal of environmental research and public health · 2022Article
- Effects of Interval Training Under Hypoxia on Hematological Parameters, Hemodynamic Function, and Endurance Exercise Performance in Amateur Female Runners in Korea.Frontiers in physiology · 2022Article
- Status of dental caries and associated factors in Tibetan adults: findings from the fourth China National Oral Health Survey.BMC oral health · 2020Article
- Interval Hypoxic Training Enhances Athletic Performance and Does Not Adversely Affect Immune Function in Middle- and Long-Distance Runners.International journal of environmental research and public health · 2020Article
- Effects of 2-Week Exercise Training in Hypobaric Hypoxic Conditions on Exercise Performance and Immune Function in Korean National Cycling Athletes with Disabilities: A Case Report.International journal of environmental research and public health · 2020Article
- Effects of Repetitive Altitude Training on Salivary Immunoglobulin A Secretion in Collegiate Swimmers.Journal of clinical medicine research · 2019Article
- Block vs. Traditional Periodization of HIT: Two Different Paths to Success for the World's Best Cross-Country Skier.Frontiers in physiology · 2019Article
- Effect of acute exercise and hypoxia on markers of systemic and mucosal immunity.European journal of applied physiology · 2016Article
- Exercise, immune function and respiratory infection: An update on the influence of training and environmental stress.Immunology and cell biology · 2016Review
- Circadian variation of salivary immunoglobin A, alpha-amylase activity and mood in response to repeated double-poling sprints in hypoxia.European journal of applied physiology · 2016Article
- Increased Hypoxic Dose After Training at Low Altitude with 9h Per Night at 3000m Normobaric Hypoxia.Journal of sports science & medicine · 2015Article
- Combining hypoxic methods for peak performance.Sports medicine (Auckland, N.Z.) · 2010Review
- Exercising in environmental extremes : a greater threat to immune function?Sports medicine (Auckland, N.Z.) · 2006Review
- Living high-training low: tolerance and acclimatization in elite endurance athletes.European journal of applied physiology · 2006Article
- Measles, rubella, mumps and Toxoplasma gondii antibodies in saliva of vaccinated students of schools and universities in São Paulo City, Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secretory immunoglobulin A (sIgA) is the major immunoglobulin of the mucosal immune system. Whereas the suppressive effect of heavy training on mucosal immunity is well documented, little is known regarding the influence of hypoxia exposure on sIgA during altitude training. This investigation examined the impact of an 18-day Living high-training low (LHTL) training camp on sIgA levels in 11 (six females and five males) elite cross-country skiers. Subjects from the control group (n=5) trained and lived at 1,200 m of altitude, whereas, subjects from the LHTL group (n=6) trained at 1,200 m, but lived at a simulated altitude of 2,500, 3,000 and 3,500 m (3x6-day, 11 h day(-1)) in hypoxic rooms. Saliva samples were collected before, after each 6-day phases and 2 weeks thereafter (POST). Salivary sIgA, protein and cortisol were measured. There was a downward trend in sIgA concentrations over the study, which reached significance in LHTL (P<0.01), but not in control (P=0.08). Salivary IgA concentrations were still lower baseline at POST (P<0.05). Protein concentration increased in LHTL (P<0.05) and was negatively correlated with sIgA concentration after the 3,000 and 3,500 m-phase and at POST (P<0.05 all). Cortisol concentrations were unchanged over the study and no relationship was found between cortisol and sIgA. In summary, data were strongly suggestive of a cumulative negative effect of physical exercise and hypoxia on sIgA levels during LHTL training. Two weeks of active recovery did not allow for proper sIgA recovery. The mechanism underlying this depression of sIgA could be mediated by neural factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.