Trial reportEuropean journal of nuclear medicine and molecular imaging2005
In vivo uptake of [11C]choline does not correlate with cell proliferation in human prostate cancer.
Trial report in European journal of nuclear medicine and molecular imaging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 112 citations in OpenAlex.
- 18F-Choline PET/MRI: The Additional Value of PET for MRI-Guided Transrectal Prostate Biopsies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Trial
- Detection of aggressive primary prostate cancer with 11C-choline PET/CT using multimodality fusion techniques.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2009Trial
- Molecular Imaging in Multiple Myeloma-Novel PET Radiotracers Improve Patient Management and Guide Therapy.Frontiers in nuclear medicine · 2022Review
- Combined bone scintigraphy and fluorocholine PET/computed tomography predicts response to radium-223 therapy in patients with prostate cancer.Future science OA · 2021Article
- Kinetic analysis of dominant intraprostatic lesion of prostate cancer using quantitative dynamic [EJNMMI research · 2021Article
- Choline PET/CT in Multiple Myeloma.Cancers · 2020Review
- Detection Rate ofContrast media & molecular imaging · 2020Article
- PET and PET/CT with radiolabeled choline in prostate cancer: a critical reappraisal of 20 years of clinical studies.European journal of nuclear medicine and molecular imaging · 2017Review
- PET Tracers Beyond FDG in Prostate Cancer.Seminars in nuclear medicine · 2016Review
- Usefulness of MRI-assisted metabolic volumetric parameters provided by simultaneous (18)F-fluorocholine PET/MRI for primary prostate cancer characterization.European journal of nuclear medicine and molecular imaging · 2015Article
- Potential of hybrid ¹⁸F-fluorocholine PET/MRI for prostate cancer imaging.European journal of nuclear medicine and molecular imaging · 2014Article
- Comparison of PET imaging with a (68)Ga-labelled PSMA ligand and (18)F-choline-based PET/CT for the diagnosis of recurrent prostate cancer.European journal of nuclear medicine and molecular imaging · 2014Article
- Kinetic Modeling Application to (18)F-fluoroethylcholine Positron Emission Tomography in Patients with Primary and Recurrent Prostate Cancer Using Two-tissue Compartmental Model.World journal of nuclear medicine · 2013Article
- Functional and molecular imaging: applications for diagnosis and staging of localised prostate cancer.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2013Review
- Characterization of primary prostate carcinoma by anti-1-amino-2-[(18)F] -fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) uptake.American journal of nuclear medicine and molecular imaging · 2013Article
- Imaging primary prostate cancer with 11C-Choline PET/CT: relation to tumour stage, Gleason score and biomarkers of biologic aggressiveness.Radiology and oncology · 2012Article
- Functional imaging for prostate cancer: therapeutic implications.Seminars in nuclear medicine · 2012Review
- Molecular imaging of prostate cancer: PET radiotracers.AJR. American journal of roentgenology · 2012Review
- [Choline PET/CT in the diagnosis of primary and recurrent prostate cancer. Are there evidence-based indications?].Der Urologe. Ausg. A · 2012Review
- Targeting free prostate-specific antigen for in vivo imaging of prostate cancer using a monoclonal antibody specific for unique epitopes accessible on free prostate-specific antigen alone.Cancer biotherapy & radiopharmaceuticals · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProstate cancer is the second leading cause of death from cancer among US men. Positron emission tomography (PET) with [(11)C]choline has been shown to be useful in the staging and detection of prostate cancer. The background of the increased uptake of choline in human prostate cancer is not completely understood. The aim of this study was to prospectively investigate the relationship between the [(11)C]choline uptake and the cell proliferation in human prostate cancer.
methodsProstate cancer tissue from 18 patients who had undergone a radical prostatectomy for histologically proven disease was studied. An [(11)C]choline PET scan was performed prior to surgery. Post-prostatectomy specimens were prepared and stained with the antibody MIB-1 for Ki-67, which depicts proliferation. Two independent observers counted the amount of stained nuclei per specimen.
resultsProstate cancer showed Ki-67 staining and high uptake of [(11)C]choline. Statistical analysis showed no significant correlation between [(11)C]choline uptake and Ki-67 staining (R=0.23; P=0.34). No significant relationships were found between the uptake of [(11)C]choline (SUV) and either preoperative PSA (R=0.14; P=0.55) or Gleason sum score (R=0.28; P=0.25).
conclusionIn vivo uptake of [(11)C]choline does not correlate with cell proliferation in human prostate cancer as depicted by Ki-67. Our results suggest that a process other than proliferation is responsible for the uptake of [(11)C]choline in prostate cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.