ArticleBiophysical journal2005
Differences in the modulation of collective membrane motions by ergosterol, lanosterol, and cholesterol: a dynamic light scattering study.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment.Pharmaceutics · 2025Article
- Dynamic Light Scattering Measurements for Soft Materials on Solid Substrates: Employing Evanescent-wave Illumination and Dark-field Collection with a High Numerical Aperture Microscope Objective.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Article
- Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth.Journal of lipid research · 2015Article
- Article
- Effect of cholesterol on the lateral nanoscale dynamics of fluid membranes.European biophysics journal : EBJ · 2012Article
- Influence of cholesterol on the collective dynamics of the phospholipid acyl chains in model membranes.The European physical journal. E, Soft matter · 2010Article
- Coupled diffusion of peripherally bound peptides along the outer and inner membrane leaflets.Biophysical journal · 2009Article
- Differential modulation of membrane structure and fluctuations by plant sterols and cholesterol.Biophysical journal · 2008Article
- Phase behavior of a model bilayer membrane with coupled leaves.Biophysical journal · 2008Article
- Comparative calorimetric and spectroscopic studies of the effects of lanosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes.Biophysical journal · 2006Article
- Phase separation in bilayer lipid membranes: effects on the inner leaf due to coupling to the outer leaf.Biophysical journal · 2006Article
- Domain-formation in DOPC/SM bilayers studied by pfg-NMR: effect of sterol structure.Biophysical journal · 2006Article
- Lipid asymmetry in DLPC/DSPC-supported lipid bilayers: a combined AFM and fluorescence microscopy study.Biophysical journal · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A dynamic light scattering setup was used to study the undulations of freely suspended planar lipid bilayers, the so-called black lipid membranes, over a previously inaccessible range of frequency and wave number. A pure synthetic lecithin bilayer, 1,2-dielaidoyl-sn-3-glycero-phoshatidylcholine (DEPC), and binary mixtures of DEPC with 40 mol % of cholesterol, ergosterol, or lanosterol were studied. By analyzing the dynamic light scattering data (oscillation and damping curves) in terms of transverse shear motion, we extracted the lateral tension and surface viscosity of the composite bilayers for each sterol. Cholesterol gave the strongest increase in lateral tension (approximately sixfold) with respect to the DEPC control, followed by lanosterol (approximately twofold), and ergosterol (1.7-fold). Most interestingly, only cholesterol simultaneously altered the surface viscosity of the bilayer by almost two orders of magnitude, whereas the other two sterols did not affect this parameter. We interpret this unique behavior of cholesterol as a result of its previously established out-of-plane motion which allows the molecule to cross the bilayer midplane, thereby effectively coupling the bilayer leaflets to form a highly flexible but more stable composite membrane.
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