ArticleWorld journal of gastroenterology2005
Tumor angiogenesis and dynamic CT in colorectal carcinoma: radiologic-pathologic correlation.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- An application study of low-dose computed tomography perfusion imaging for evaluation of the efficacy of neoadjuvant chemotherapy for advanced gastric adenocarcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2018Trial
- Higher perfusion of rectum carcinoma relative to tumor-free rectal wall: quantification by a new imaging biomarker diffusion-derived vessel density (DDVD).Quantitative imaging in medicine and surgery · 2024Article
- Correlation between color doppler flow pattern and molecular biology in elderly patients with colon cancer.BMC gastroenterology · 2023Article
- Does perfusion computed tomography correlate to pathology in colorectal liver metastases?PloS one · 2021Article
- Conspicuity of prostate cancer on multiparametric magnetic resonance imaging: A cross-disciplinary translational hypothesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Impact of Variability in Portal Venous Phase Acquisition Timing in Tumor Density Measurement and Treatment Response Assessment: Metastatic Colorectal Cancer as a Paradigm.JCO clinical cancer informatics · 2017Article
- Correlation between CT perfusion and clinico-pathological features in prostate cancer: a prospective study.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Integrated ¹⁸F-FDG PET/perfusion CT for the monitoring of neoadjuvant chemoradiotherapy in rectal carcinoma: correlation with histopathology.European journal of nuclear medicine and molecular imaging · 2014Article
- Perfusion CT imaging of colorectal cancer.The British journal of radiology · 2014Review
- Article
- Assessment of blood flow in hepatocellular carcinoma: correlations of computed tomography perfusion imaging and circulating angiogenic factors.International journal of molecular sciences · 2013Article
- Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects.Diagnostics (Basel, Switzerland) · 2013Article
- Perfusion CT to assess angiogenesis in colon cancer: technical limitations and practical challenges.The British journal of radiology · 2012Article
- Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method.European radiology · 2012Article
- Esophageal squamous cell carcinoma: assessing tumor angiogenesis using multi-slice CT perfusion imaging.Digestive diseases and sciences · 2012Article
- Current status and guidelines for the assessment of tumour vascular support with dynamic contrast-enhanced computed tomography.European radiology · 2012Article
- Protocol modifications for CT perfusion (CTp) examinations of abdomen-pelvic tumors: impact on radiation dose and data processing time.European radiology · 2011Article
- Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer.European radiology · 2011Article
- Demonstrating Intertumoural Differences in Vascular-Metabolic Phenotype with Dynamic Contrast-Enhanced CT-PET.International journal of molecular imaging · 2011Article
- Perfusion CT in solid body-tumours. Part II: Clinical applications and future development.La Radiologia medica · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the correlation between microvessel density and spiral CT perfusion imaging in colorectal carcinoma.
methodsThirty-seven patients, with histologically proven colorectal carcinoma, underwent water enema spiral CT scan. The largest axial surface of the primary tumor was searched on unenhanced spiral CT images. At this level, the enhanced dynamic scan series was acquired. Time-density curves (TDC) were created from the region of interest drawn over the tumor, target artery by Toshiba Xpress/SX spiral CT with perfusion functional software. Then the perfusion was calculated. Microvessel density (MVD) was evaluated using immunohistochemical staining of surgical specimens with anti-CD34, and then MVD was correlated with perfusion.
resultsMVD of colorectal carcinomas was 33.11-173.44, mean 87.28, and perfusion was 15.60-64.80 mL/min/100 g, mean 39.74 mL/min/100 g. MVD and perfusion were not associated with invasive depth, metastasis and disease stage, and they all decreased with increasing Dukes' stage, but no significant correlation was found between them (r = 0.18, P = 0.29).
conclusionThere is no significant correlation between MVD and perfusion. Neovascularizaton and perfusion are highly presented in early colorectal carcinoma. CT perfusion imaging may be more suited for assessing tumorigenesis in colorectal carcinoma than histological MVD technique.
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