ReviewThe Journal of physiology2005
The effects of anaemia as a programming agent in the fetal heart.
Review in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Automated quantitative evaluation of fetal atrioventricular annular plane systolic excursion before and after intrauterine blood transfusion in pregnancies affected by red blood cell alloimmunization.Acta obstetricia et gynecologica Scandinavica · 2024Observational
- Decreased fetal cardiac output in pregnant women with severe SARS-Cov-2 infection.Echocardiography (Mount Kisco, N.Y.) · 2022Article
- Fetal brain sparing in a mouse model of chronic maternal hypoxia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- The effects of embryonic hypoxic programming on cardiovascular function and autonomic regulation in the American alligator (Alligator mississippiensis) at rest and during swimming.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Chronic hypoxia alters maternal uterine and fetal hemodynamics in the full-term pregnant guinea pig.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- N-terminal pro-B-type natriuretic peptide in amniotic fluid of fetuses with known or suspected cardiac load.PloS one · 2017Article
- Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Fetal in vivo continuous cardiovascular function during chronic hypoxia.The Journal of physiology · 2016Article
- The fetal brain sparing response to hypoxia: physiological mechanisms.The Journal of physiology · 2016Review
- The programming of cardiovascular disease.Journal of developmental origins of health and disease · 2015Review
- How to build a healthy heart from scratch.Advances in experimental medicine and biology · 2014Review
- Effect of in utero and early-life conditions on adult health and disease.The New England journal of medicine · 2008Review
- Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot study.Reproductive biology and endocrinology : RB&E · 2008Article
- In utero exposure to environmental tobacco smoke potentiates adult responses to allergen in BALB/c mice.Environmental health perspectives · 2007Article
- Molecular, cellular and endocrine signalling in the perinatal cardiovascular system: interplay and developmental programming.The Journal of physiology · 2005Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The intrauterine environment plays a powerful role in determining the life-long risk of cardiovascular disease. A number of stressors are well known to affect the development of the cardiovascular system in utero including over/under maternal nutrition, excess glucocorticoid and chronic hypoxia. Chronic fetal anaemia in sheep is a complex stressor that alters cardiac loading conditions, causes hypoxic stress and stimulates large changes in flow to specific tissues, including large increases in resting coronary blood flow and conductance. Decreased viscosity can account for approximately half of the increased flow. It appears that immature hearts are 'plastic' in that increases in coronary conductance with fetal anaemia persist into adulthood even if the anaemia is corrected before birth. These large changes in conductance are possible only through extensive remodelling of the coronary tree. Adult hearts that were once anaemic in utero are more resistant to hypoxic stress as adults but it is not known whether such an adaptation would be deleterious in later life. These studies indicate the need for investigation into the basic mechanisms of coronary tree remodelling in the immature myocardium. New information on these mechanisms is likely to lead to better prevention of and therapies for adult-onset coronary disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.