ArticleAJNR. American journal of neuroradiology2005
Myelination in children with partial deletions of chromosome 18q.
Article in AJNR. American journal of neuroradiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00227253 (The Chromosome 18 Clinical Research Center), which is not on this map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Chromosome 18 Clinical Research Center
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Imaging Findings and MRI Patterns in a Cohort of 18q Chromosomal Abnormalities.AJNR. American journal of neuroradiology · 2024Article
- Hypomyelinating disorders in China: The clinical and genetic heterogeneity in 119 patients.PloS one · 2018Article
- Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia.Genes, brain, and behavior · 2017Article
- A New Strategy for Fast MRI-Based Quantification of the Myelin Water Fraction: Application to Brain Imaging in Infants.PloS one · 2016Article
- Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia.Human brain mapping · 2015Article
- Sensorineural hearing loss in people with deletions of 18q: hearing in 18q-.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2014Article
- White matter characterization with diffusional kurtosis imaging.NeuroImage · 2011Article
- Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging.NeuroImage · 2010Article
- Narrowing critical regions and determining penetrance for selected 18q- phenotypes.American journal of medical genetics. Part A · 2009Article
- Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalization.Human brain mapping · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeWe compared myelin levels in white matter (WM) in typically developing children with those of children with partial deletions of chromosome 18q (18q-).
methodsConventional spin-echo MR imaging at 1.9T was used to acquire T1-, T2-, and proton density-weighted images of the brain. From these images, a three-pool model was used to estimate the fraction of water in myelin, myelinated axon, and mixed water compartments (or pools) in six WM regions. A model curve was fit to the pool fractions to model the trend of myelin development by age in each region. Water-pool fractions in children with 18q- aged 5 months to 13 years were compared with those of age-matched, typically developing children.
resultsIn children with 18q-, the model predicted later onset of myelination (P <.02), lower myelination rates (P <.001), and smaller equilibrium myelin pool fractions (P <.001). Significant differences were seen between the two groups for all three water pool fractions (P <.001). The mixed pool fraction was larger in children with 18q-. Although the myelin pool fraction was significantly smaller, the myelinated axon pool fraction was only slightly smaller, leading to a significantly smaller estimate of myelin per myelinated axon in children with 18q- (P <.001).
conclusionMyelination modeling in 18q- children indicated delayed onset, a lower rate of myelination, and equilibrium myelin levels less than 50% those of age-matched, typically developing children.
Indexed as
Identifiers
15760848PMC7976464W2168882563What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.