ArticleCellular microbiology2005
Suppression of NF-kappaB-mediated beta-defensin gene expression in the mammalian airway by the Bordetella type III secretion system.
Article in Cellular microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Limited response of primary nasal epithelial cells toMicrobiology spectrum · 2025Article
- Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue.PLoS pathogens · 2020Article
- Review
- Article
- Differential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Rediscovering Pertussis.Frontiers in pediatrics · 2016Review
- Comparison of innate immune agonists for induction of tracheal antimicrobial peptide gene expression in tracheal epithelial cells of cattle.Veterinary research · 2014Article
- Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity.Journal of leukocyte biology · 2011Article
- Modulation of NF-κB signalling by microbial pathogens.Nature reviews. Microbiology · 2011Review
- Transcriptional profiling avian beta-defensins in chicken oviduct epithelial cells before and after infection with Salmonella enterica serovar Enteritidis.BMC microbiology · 2009Article
- The roles of antimicrobial peptides in innate host defense.Current pharmaceutical design · 2009Review
- Host defense peptides in the oral cavity and the lung: similarities and differences.Journal of dental research · 2008Review
- Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice.American journal of respiratory and critical care medicine · 2008Article
- Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin.PloS one · 2008Article
- Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3).Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2007Article
- Pattern recognition receptors in companion and farm animals - the key to unlocking the door to animal disease?Veterinary journal (London, England : 1997) · 2007Review
- Effect of corticosteroids and neuropeptides on the expression of defensins in bovine tracheal epithelial cells.Infection and immunity · 2007Article
- In vivo beta-defensin gene expression in rat gingival epithelium in response to Actinobacillus actinomycetemcomitans infection.Journal of periodontal research · 2006Article
- Inhibition of beta-defensin gene expression in airway epithelial cells by low doses of residual oil fly ash is mediated by vanadium.Toxicological sciences : an official journal of the Society of Toxicology · 2006Article
- The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of innate immune genes such as beta-defensins is induced in airway epithelium by bacterial components via activation of NF-kappaB. We show here that live Gram-negative bacteria can similarly stimulate this pathway, resulting in upregulation of the beta-defensin tracheal antimicrobial peptide (TAP) in primary cultures of bovine tracheal epithelial cells (TECs), by a Toll-like receptor 4 (TLR4)-mediated pathway. The Gram-negative airway pathogen Bordetella bronchiseptica possesses a type III secretion system previously suggested to inhibit the nuclear translocation of NF-kappaB in a cell line by immunohistochemistry. We therefore hypothesized that this pathogen might interfere in the innate immune response of the epithelium. Exposure of TECs to wild-type B. bronchiseptica suppressed the activation of NF-kappaB and the subsequent induction of TAP mRNA levels, whereas a type III secretion-defective strain did not. These results suggest a mechanism for bacterial evasion of the innate immune response in the airway, which could allow for the observed persistent colonization of this pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.