ArticleAAPS PharmSciTech2004
Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods.
Article in AAPS PharmSciTech, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Chitosan-Based Nanoencapsulation of Mānuka Oil for Periodontal Treatment.International journal of molecular sciences · 2025Review
- Crosslinked chitosan microparticles as a safe and efficient DNA carrier for intranasal vaccination against cutaneous leishmaniasis.Vaccine: X · 2023Article
- Chitosan-coated halloysite nanotube magnetic microspheres for carcinogenic colorectal hemorrhage and liver laceration in albino rats.RSC advances · 2023Article
- Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release.Pharmaceutics · 2023Review
- Mucoadhesive Marine Polysaccharides.Marine drugs · 2022Review
- Article
- Tragacanth Gum/Chitosan Polyelectrolyte Complexes-Based Hydrogels Enriched with Xanthan Gum as Promising Materials for Buccal Application.Materials (Basel, Switzerland) · 2020Article
- Novel Approaches for the Treatment of Pulmonary Tuberculosis.Pharmaceutics · 2020Review
- Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems.International journal of biological macromolecules · 2020Article
- Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review.Polymers · 2020Review
- Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments.Polymers · 2020Review
- Hydrogel Delivery System ContainingPharmaceutics · 2020Article
- Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein-Drug Delivery System.Materials (Basel, Switzerland) · 2020Article
- Interaction Between Chitosan and Mucin: Fundamentals and Applications.Biomimetics (Basel, Switzerland) · 2019Review
- Insights into gold nanoparticles as a mucoadhesive system.Scientific reports · 2018Article
- Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections.Pharmaceutical research · 2015Article
- Biomaterials for nanoparticle vaccine delivery systems.Pharmaceutical research · 2014Review
- Viper and cobra venom neutralization by alginate coated multicomponent polyvalent antivenom administered by the oral route.PLoS neglected tropical diseases · 2014Article
- Comparative study of various delivery methods for the supply of alpha-ketoglutarate to the neural cells for tissue engineering.BioMed research international · 2013Article
- Preparation and characterization of novel multi-core chitosan microspheres for stomach-specific delivery of hydrophilic antibiotics.Journal of materials science. Materials in medicine · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mucoadhesive properties of chitosan microspheres prepared by different methods were evaluated by studying the interaction between mucin and microspheres in aqueous solution. The interaction was determined by the measurement of mucin adsorbed on the microspheres. A strong interaction between chitosan microspheres and mucin was detected. The intensity of the interaction was dependent upon the method of preparation of chitosan microspheres and the amount of mucin added. The extent of mucus adsorption was proportional to the absolute values of the positive zeta potential of chitosan microspheres. The zeta potential in turn was found to be dependent upon the method of preparation of microspheres. The adsorption of type III mucin (1% sialic acid content) was interpreted using Freundlich or Langmuir adsorption isotherms. The values of r2 were greater for Langmuir isotherm as compared with Freundlich isotherm. The adsorption of a suspension of chitosan microspheres in the rat small intestine indicated that chitosan microspheres prepared by tripolyphosphate cross-linking and emulsification ionotropic gelation can be used as an excellent mucoadhesive delivery system. The microspheres prepared by glutaraldehyde and thermal cross-linking showed good stability in HCl as compared with microspheres prepared by tripolyphosphate and emulsification ionotropic gelation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.