ArticleJournal of molecular modeling2005
Molecular models of protein targets from Mycobacterium tuberculosis.
Article in Journal of molecular modeling, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 20 citations in OpenAlex.
- Exploring the Scoring Function Space with Lasso Regression.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Review
- SKPDB: a structural database of shikimate pathway enzymes.BMC bioinformatics · 2010Article
- Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP.Journal of molecular modeling · 2009Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural characterization of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design since some of these proteins may be present in the bacterial genome, but absent in humans. Thus, metabolic pathways became potential targets for drug design. The motivation of this work is the fact that Mycobacterium tuberculosis is the cause of the deaths of millions of people in the world, so that the structural characterization of protein targets to propose new drugs has become essential. DBMODELING is a relational database, created to highlight the importance of methods of molecular modeling applied to the Mycobacterium tuberculosis genome with the aim of proposing protein-ligand docking analysis. There are currently more than 300 models for proteins from Mycobacterium tuberculosis genome in the database. The database contains a detailed description of the reaction catalyzed by each enzyme and their atomic coordinates. Information about structures, a tool for animated gif image, a table with a specification of the metabolic pathway, modeled protein, inputs used in modeling, and analysis methods used in this project are available in the database for download. The search tool can be used for researchers to find specific pathways or enzymes.
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Registered trials
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