ArticleImmunogenetics2005
A novel tumor necrosis factor (TNF) gene present in tandem with theTNF-alpha gene on the same chromosome in teleosts.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 96 citations in OpenAlex.
- Functional Characterization ofAnimals : an open access journal from MDPI · 2025Article
- Article
- Fish TNF and TNF receptors.Science China. Life sciences · 2021Review
- Tumor Necrosis Factor Superfamily: Ancestral Functions and Remodeling in Early Vertebrate Evolution.Genome biology and evolution · 2020Article
- Identification of a Distal Locus Enhancer Element That Controls Cell Type-SpecificJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.Nature communications · 2018Article
- Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds.Frontiers in immunology · 2018Article
- The Change of Teleost Skin Commensal Microbiota Is Associated With Skin Mucosal Transcriptomic Responses During Parasitic Infection byFrontiers in immunology · 2018Article
- Molecular characterisation of tumour necrosis factor alpha and its potential connection with lipoprotein lipase and peroxisome proliferator-activated receptors in blunt snout bream (Megalobrama amblycephala).Journal of applied genetics · 2017Article
- The Function of Fish Cytokines.Biology · 2016Review
- Biology of Bony Fish Macrophages.Biology · 2015Review
- Cytokine Gene Expression in CD4 Positive Cells of the Japanese Pufferfish, Takifugu rubripes.PloS one · 2013Article
- Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation.Advances in immunology · 2013Review
- The innate immune-related genes in catfish.International journal of molecular sciences · 2012Review
- Article
- Evolution and comparative analysis of the MHC Class III inflammatory region.BMC genomics · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factors (TNFs) are pleiotropic cytokines implicated in inflammation, apoptosis, cell proliferation, and a general stimulation of immune system. Although the TNF/lymphotoxin (LT) locus is present in the MHC region of the chromosome in mammals, no such locus has been described from teleosts. Furthermore, in teleosts only the TNF-alpha-like gene has been cloned and analyzed. In this study, for the first time in teleosts, a similar TNF locus has also been found in zebrafish and fugu. This locus harbors a new TNF ligand in tandem with TNF-alpha gene. The fugu and zebrafish TNF locus harbors TNF-alpha and TNF-N genes that are 7.5 kb and 19 kb apart from each other, respectively. Several genes associated with the TNF/LT locus in mammals are found conserved in fish as well. Fish TNF-alpha genes cloned possess a transmembrane domain, two conserved cysteines, and a conserved TNF family signature with a four-exon and three-intron genomic structure. The newly identified TNF-N genes from teleosts are present upstream of TNF-alpha genes in the same transcriptional orientation. However, the coding regions of these genes span into five and four exons in fugu and zebrafish, respectively. The transcription sites in the promoter regions of teleost TNF ligands are fairly conserved in comparison to mammals. Expression analysis indicates a constitutive expression of both the genes in fugu, while differential expression of TNF ligands is seen in zebrafish tissues.
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