ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
The nitric oxide-cGMP signaling pathway differentially regulates presynaptic structural plasticity in cone and rod cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission.Molecular neurobiology · 2025Review
- Modulating NO-GC Pathway in Pulmonary Arterial Hypertension.International journal of molecular sciences · 2023Review
- Article
- The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme.bioRxiv : the preprint server for biology · 2023Article
- Coming of Age for the Photoreceptor Synapse.Investigative ophthalmology & visual science · 2021Article
- Expression of theJournal of neurogenetics · 2021Article
- Identification of Novel Genomic-Variant Patterns of OR56A5, OR52L1, and CTSD in Retinitis Pigmentosa Patients by Whole-Exome Sequencing.International journal of molecular sciences · 2021Article
- Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro.Investigative ophthalmology & visual science · 2017Article
- Nitric oxide: what's new to NO?American journal of physiology. Cell physiology · 2017Review
- Inhibition of dopamine signaling suppresses cGMP accumulation in rd1 retinal organ cultures.Neuroreport · 2014Article
- Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.BioMed research international · 2014Article
- Early degeneration of photoreceptor synapse in Ccl2/Cx3cr1-deficient mice on Crb1(rd8) background.Synapse (New York, N.Y.) · 2013Article
- The sonic hedgehog pathway mediates brain plasticity and subsequent functional recovery after bone marrow stromal cell treatment of stroke in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Mislocalized opsin and cAMP signaling: a mechanism for sprouting by rod cells in retinal degeneration.Investigative ophthalmology & visual science · 2012Article
- EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals.Frontiers in molecular neuroscience · 2012Article
- TRP Channels as Sensors and Signal Integrators of Redox Status Changes.Frontiers in pharmacology · 2011Article
- Nicotinamide adenine dinucleotide-dependent binding of the neuronal Ca2+ sensor protein GCAP2 to photoreceptor synaptic ribbons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
- Cone and rod cells have different target preferences in vitro as revealed by optical tweezers.Molecular vision · 2008Article
- Visual pattern memory requires foraging function in the central complex of Drosophila.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
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Authors and funding
3 authors at 1 institution.
Funding
Abstract
Although abundant structural plasticity in the form of axonal retraction, neurite extension, and formation of presynaptic varicosities is displayed by photoreceptors after retinal detachment and during genetic and age-related retinal degeneration, the mechanisms involved are mostly unknown. We demonstrated recently that Ca(2+) influx through cGMP-gated channels in cones and voltage-gated L-type channels in rods is required for neurite extension in vitro (Zhang and Townes-Anderson, 2002). Here, we report that the nitric oxide (NO)-cGMP signaling pathway is active in photoreceptors and that its manipulation differentially regulates the structural plasticity of cone and rod cells. The NO receptor soluble guanylyl cyclase (sGC) was detected immunocytochemically in both cone and rod cells. Stimulation of sGC increased cGMP production in retinal cultures. In cone cells, quantitative analysis showed that NO or cGMP stimulated neuritic sprouting; this stimulatory effect was dependent on both Ca2+ influx through cGMP-gated channels and phosphorylation by protein kinase G (PKG). At the highest levels of cGMP, however, cone outgrowth was no longer increased. In rod photoreceptors, NO or cGMP consistently inhibited neuritic growth in a dose-dependent manner; this inhibitory effect required PKG. When NO-cGMP signaling was inhibited, changes in the neuritic development of cone and rod cells were also observed but in the opposite direction. These results expand the role of cGMP in axonal activity to adult neuritogenesis and suggest an explanation for the neurite sprouting observed in an autosomal recessive form of retinitis pigmentosa that is characterized by high cGMP levels in photoreceptor layers.
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