ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Continuous negative autoregulation fine-tunes dosage-sensitive transcription factor expression to maintain post-mitotic neuron identity.bioRxiv : the preprint server for biology · 2026Article
- A discrete serotonergic circuit involved in the generation of tinnitus behavior.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity.eLife · 2022Article
- Article
- RGS2 drives male aggression in mice via the serotonergic system.Communications biology · 2019Article
- p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Serotonin neuron development: shaping molecular and structural identities.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Article
- An Update on the Role of Serotonin and its Interplay with Dopamine for Reward.Frontiers in human neuroscience · 2017Review
- Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem.Brain structure & function · 2016Article
- Generation of functional human serotonergic neurons from fibroblasts.Molecular psychiatry · 2016Article
- Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons.ACS chemical neuroscience · 2015Article
- Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.The Journal of clinical investigation · 2014Article
- Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery.PloS one · 2014Article
- Serotonin gene variants are unlikely to play a significant role in the pathogenesis of the sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
- Subset specification of central serotonergic neurons.Frontiers in cellular neuroscience · 2013Review
- Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Postnatal growth defects in mice with constitutive depletion of central serotonin.ACS chemical neuroscience · 2013Article
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3 authors.
Funding
Abstract
The Pet-1 [pheochromocytoma 12 ETS (E26 transformation-specific)] gene plays a critical role in the development of serotonin (5-HT)-modulated behaviors via its control of embryonic 5-HT neuron differentiation. Pet-1 transcription is induced exclusively in 5-HT neuron postmitotic precursors before the appearance of transmitter, and its restricted expression is maintained in the adult. However, the mechanisms that direct Pet-1 expression to this single CNS neuronal cell type are unknown. Here, we show, using transgenic methods, that genomic sequences upstream, but not downstream or within the Pet-1-coding region, are sufficient for 5-HT neuron-specific transgene expression. Enhancer sequences within a 40 kb upstream fragment directed position-independent lacZ (beta-D-galactosidase) transgene expression to the developing hindbrain before the appearance of 5-HT. Moreover, virtually all of the 5-HT neurons in the adult were lacZ positive in all of the lines examined. Transgene expression in 5-HT neurons was maintained when the 40 kb fragment was truncated on its 5' end to either 12 or 1.8 kb, although position independence was then lost. Analysis of transgene expression in Pet-1 null mice indicated that Pet-1 was required to maintain the activity of the Pet-1 enhancer region in a subset of 5-HT neurons. These findings suggest that a conserved 1.8 kb region immediately flanking the Pet-1-coding region is a critical genomic target of the transcriptional cascade that governs 5-HT neuron development and provide additional evidence for 5-HT neuron heterogeneity at the genetic level. We discuss the potential application of the Pet-1 transgenes reported here to the selective genetic manipulation of 5-HT neurons.
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