ArticleNeurochemical research2005
Quantitative proteomic analysis of mitochondria from primary neuron cultures treated with amyloid beta peptide.
Article in Neurochemical research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- Effect of β-amyloid on blood-brain barrier properties and function.Biophysical reviews · 2023Review
- Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients.Journal of proteomics · 2018Article
- Physiological and Pathological Roles of 15-Deoxy-ΔMolecular neurobiology · 2018Review
- Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease.Oxidative medicine and cellular longevity · 2018Review
- Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.eLife · 2017Article
- Clinical implications from proteomic studies in neurodegenerative diseases: lessons from mitochondrial proteins.Expert review of proteomics · 2016Review
- Genomics and proteomics in solving brain complexity.Molecular bioSystems · 2013Review
- Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications.Antioxidants & redox signaling · 2012Review
- Comparative mitochondrial proteomics: perspective in human diseases.Journal of hematology & oncology · 2012Review
- Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane.PloS one · 2011Article
- Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2010Article
- Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice.Cellular and molecular neurobiology · 2009Article
- Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells.Molecular psychiatry · 2008Article
- Cofilin-mediated neurodegeneration in Alzheimer's disease and other amyloidopathies.Molecular neurobiology · 2007Review
- Characterization of the mouse brain proteome using global proteomic analysis complemented with cysteinyl-peptide enrichment.Journal of proteome research · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Increasing evidence supports a role for altered mitochondrial function in the pathogenesis of neuron degeneration in Alzheimer's disease (AD). Although several studies have examined the effect of amyloid beta peptide (Abeta), on activities of individual proteins in primary neuron cultures, there have been no studies of the effects of Abeta on the mitochondrial proteome. Here, we quantitatively measured changes in mitochondrial proteins of primary rat cortical neuron cultures exposed to 25 microM Abeta(25-35) for 16 h using isotope coded affinity tag (ICAT) labeling and 2-dimensional liquid chromatography/tandem mass spectrometry (2D-LC/MS/MS) which allows simultaneous identification and quantification of cysteine-containing proteins. The analysis of enriched mitochondrial fractions identified 10 proteins including sodium/potassium-transporting ATPase, cofilin, dihydropyrimidinase, pyruvate kinase and voltage dependent anion channel 1 that were statistically significantly (P < 0.05) altered in Abeta-treated cultures. Elevations of proteins associated with energy production suggest that cells undergoing Abeta-mediated apoptosis increase synthesis of proteins essential for ATP production and efflux in an attempt to maintain metabolic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.