ArticleEuropean biophysics journal : EBJ2005
Computing numerically the access resistance of a pore.
Article in European biophysics journal : EBJ, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 51 citations in OpenAlex.
- Ion transport in biological ion channels beyond classical electrostatics. Nanoscale confinement, non-linear concentration patterns and interfacial effects.Biophysical reviews · 2026Review
- Colloquium: Ionic phenomena in nanoscale pores through 2D materials.Reviews of modern physics · 2019Article
- Robust Sandwich-Structured Nanofluidic Diodes Modulating Ionic Transport for an Enhanced Electrochromic Performance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Golden aspect ratio for ion transport simulation in nanopores.Physical review. E · 2018Article
- Maxwell-Hall access resistance in graphene nanopores.Physical chemistry chemical physics : PCCP · 2018Article
- Effect of endosomal acidification on small ion transport through the anthrax toxin PAFEBS letters · 2017Article
- Aberrantly Large Single-Channel Conductance of Polyhistidine Arm-Containing Protein Nanopores.Biochemistry · 2017Article
- Validity of the Electrodiffusion Model for Calculating Conductance of Simple Ion Channels.The journal of physical chemistry. B · 2017Article
- Article
- Interacting ions in biophysics: real is not ideal.Biophysical journal · 2013Review
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Probing Access Resistance of Solid-state Nanopores with a Scanning Probe Microscope Tip.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume.The Journal of general physiology · 2011Article
- Functionalization of micro- and nano-apertures with chromate-selective solvent polymeric membrane.Analytica chimica acta · 2010Article
- Exploring Multidimensional Free Energy Landscapes Using Time-Dependent Biases on Collective Variables.Journal of chemical theory and computation · 2010Article
- Temperature dependence of proton permeation through a voltage-gated proton channel.The Journal of general physiology · 2009Article
- Extracellular space attenuates the effect of gap junctional remodeling on wave propagation: a computational study.Biophysical journal · 2009Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
The access resistance (AR) of a channel is an important component of the conductance of ion channels, particularly in wide and short channels, where it accounts for a substantial fraction of the total resistance to the movement of ions. The AR is usually calculated by using a classical and simple expression derived by Hall from electrostatics (J.E. Hall 1975 J. Gen. Phys. 66:531-532), though other expressions, both analytical and numerical, have been proposed. Here we report some numerical results for the AR of a channel obtained by solving the Poisson-Nernst-Planck equations at the entrance of a circular pore. Agreement is found between numerical calculations and analytical results from Hall's equation for uncharged pores in neutral membranes. However, for channels embedded in charged membranes, Hall's expression overestimates the AR, which is much lower and can even be neglected in some cases. The weak dependence of AR on the pore radius for charged membranes at low salt concentration can be exploited to separate the channel and the access contributions to the measured conductance.
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