ArticleImmunogenetics2005
Recombination and the origin of sequence diversity in the DRB MHC class II locus in chamois (Rupicapra spp.).
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 47 citations in OpenAlex.
- Molecular Characterization of MHC Class I Genes in Four Species of theBioMed research international · 2021Article
- Evolution of major histocompatibility complex class I genes in the sableEcology and evolution · 2020Article
- Origin and evolution of the major histocompatibility complex class I region in eutherian mammals.Ecology and evolution · 2019Article
- Evolution of MHC class I genes in Eurasian badgers, genus Meles (Carnivora, Mustelidae).Heredity · 2019Article
- Polymorphism in the major histocompatibility complex (MHC class II B) genes of the Rufous-backed Bunting (PeerJ · 2017Article
- Article
- Recombination and selection in the major histocompatibility complex of the endangered forest musk deer (Moschus berezovskii).Scientific reports · 2015Article
- Introgression from domestic goat generated variation at the major histocompatibility complex of Alpine ibex.PLoS genetics · 2014Article
- Balancing selection and genetic drift at major histocompatibility complex class II genes in isolated populations of golden snub-nosed monkey (Rhinopithecus roxellana).BMC evolutionary biology · 2012Article
- Applicability of major histocompatibility complex DRB1 alleles as markers to detect vertebrate hybridization: a case study from Iberian ibex × domestic goat in southern Spain.Acta veterinaria Scandinavica · 2012Article
- Independent evolution of functional MHC class II DRB genes in New World bat species.Immunogenetics · 2012Article
- Evidence for evolutionary convergence at MHC in two broadly distributed mesocarnivores.Immunogenetics · 2012Article
- Sex-specific selection for MHC variability in Alpine chamois.BMC evolutionary biology · 2012Article
- Is promiscuity associated with enhanced selection on MHC-DQα in mice (genus Peromyscus)?PloS one · 2012Article
- Characterization and evolution of MHC class II B genes in Ardeid birds.Journal of molecular evolution · 2011Article
- MHC class II DRB diversity in raccoons (Procyon lotor) reveals associations with raccoon rabies virus (Lyssavirus).Immunogenetics · 2011Article
- Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri).Immunogenetics · 2010Article
- Sequence polymorphism and geographical variation at a positively selected MHC-DRB gene in the finless porpoise (Neophocaena phocaenoides): implication for recent differentiation of the Yangtze finless porpoise?Journal of molecular evolution · 2010Article
- Polymorphism, haplotype composition, and selection in the Mhc-DRB of wild baboons.Immunogenetics · 2008Article
- Selection, diversity and evolutionary patterns of the MHC class II DAB in free-ranging Neotropical marsupials.BMC genetics · 2008Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the evolutionary processes contributing to genetic diversity at the major histocompatibility complex (MHC) class II DRB locus in chamois (Rupicapra spp., subfamily Caprinae). We characterised the pattern of intragenic recombination (or homologous gene conversion) and quantified the amount of recombination in the genealogical history of the two chamois species, Pyrenean chamois (Rupicapra pyrenaica) and Alpine chamois (Rupicapra rupicapra). We found evidence for intragenic recombination, and the estimated amount of population recombination suggests that recombination has been a significant process in generating DRB allelic diversity in the genealogical history of the genus Rupicapra. Moreover, positive selection appears to act on the same peptide-binding residues in both analysed chamois species, but not in identical intensity. Recombination coupled with positive selection drives the rapid evolution at the peptide-binding sites in the MHC class II DRB gene. Many chamois MHC class II DRB alleles are thus much younger than previously assumed.
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