ReviewMicrobiology and molecular biology reviews : MMBR2005
Diversifying carotenoid biosynthetic pathways by directed evolution.
Review in Microbiology and molecular biology reviews : MMBR, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Carotenoids of Halophilic Archaea: Production, Properties and Biotechnological Applications.Probiotics and antimicrobial proteins · 2026Review
- Systematic CRISPRi screening reveals genetic modulators ofbioRxiv : the preprint server for biology · 2026Article
- Fecal Microbiome Analysis Distinguishes Bacterial Taxa Biomarkers Associated with Red Fillet Color in Rainbow Trout.Microorganisms · 2023Article
- Molecular characterization of cyanobacterial short-chain prenyltransferases and discovery of a novel GGPP phosphatase.The FEBS journal · 2022Article
- Functional verification and characterization of a type-III geranylgeranyl diphosphate synthase gene fromFrontiers in microbiology · 2022Article
- Roles of plastid-located phosphate transporters in carotenoid accumulation.Frontiers in plant science · 2022Review
- Biochemical and Immunological implications of Lutein and Zeaxanthin.International journal of molecular sciences · 2021Review
- The number of catalytic cycles in an enzyme's lifetime and why it matters to metabolic engineering.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Atlantic Salmon (Salmo salar L., 1758) Gut Microbiota Profile Correlates with Flesh Pigmentation: Cause or Effect?Marine biotechnology (New York, N.Y.) · 2020Article
- Light-driven carbon-carbon bond formation via COProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes.Frontiers in pharmacology · 2020Review
- Challenges and tackles in metabolic engineering for microbial production of carotenoids.Microbial cell factories · 2019Review
- Genetically engineered biosynthetic pathways for nonnatural CScientific reports · 2019Article
- Construction of a pathway to C50-ε-carotene.PloS one · 2019Article
- In Vitro Anticancer Activity of Staphyloxanthin Pigment Extracted fromIndian journal of microbiology · 2018Article
- Genomewide characterisation of the genetic diversity of carotenogenesis in bacteria of the order Sphingomonadales.Microbial genomics · 2018Article
- Seed Endophyte Microbiome of Crotalaria pumila Unpeeled: Identification of Plant-Beneficial Methylobacteria.International journal of molecular sciences · 2018Article
- Characterization and Salt Response in Recurrent HalotolerantFrontiers in microbiology · 2018Article
- A plug-and-play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae.Biotechnology and bioengineering · 2017Article
- Filamentous ascomycetes fungi as a source of natural pigments.Fungal biology and biotechnology · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microorganisms and plants synthesize a diverse array of natural products, many of which have proven indispensable to human health and well-being. Although many thousands of these have been characterized, the space of possible natural products--those that could be made biosynthetically--remains largely unexplored. For decades, this space has largely been the domain of chemists, who have synthesized scores of natural product analogs and have found many with improved or novel functions. New natural products have also been made in recombinant organisms, via engineered biosynthetic pathways. Recently, methods inspired by natural evolution have begun to be applied to the search for new natural products. These methods force pathways to evolve in convenient laboratory organisms, where the products of new pathways can be identified and characterized in high-throughput screening programs. Carotenoid biosynthetic pathways have served as a convenient experimental system with which to demonstrate these ideas. Researchers have mixed, matched, and mutated carotenoid biosynthetic enzymes and screened libraries of these "evolved" pathways for the emergence of new carotenoid products. This has led to dozens of new pathway products not previously known to be made by the assembled enzymes. These new products include whole families of carotenoids built from backbones not found in nature. This review details the strategies and specific methods that have been employed to generate new carotenoid biosynthetic pathways in the laboratory. The potential application of laboratory evolution to other biosynthetic pathways is also discussed.
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