ArticleEukaryotic cell2005
Aspergillus lentulus sp. nov., a new sibling species of A. fumigatus.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.
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Who cites it
154 citing papers in PubMed.
- A case of feline aspergillosis with central nervous system involvement: clinical utility of cerebrospinal fluid PCR testing.The Journal of veterinary medical science · 2026Article
- Pathogenic Mechanisms of Aspergillus lentulus Infection: Induction of Oxidative Stress and Tissue Damage in Galleria mellonella Larvae.Mycopathologia · 2026Article
- BeyondAntimicrobial agents and chemotherapy · 2026Article
- Article
- Case Report: Invasive pulmonary aspergillosis caused byFrontiers in medicine · 2026Article
- Genetic analysis of common triazole resistance mechanisms in a collection ofAntimicrobial agents and chemotherapy · 2025Article
- Appearance of Environment-Linked Azole Resistance in the Aspergillus fumigatus Complex in New Zealand.Mycoses · 2025Article
- Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression.Scientific reports · 2025Article
- High prevalence of azole resistance among environmentalFrontiers in microbiology · 2025Article
- Comparison of Morphological, Virulence, and Antifungal Susceptibility Characteristics WithinInfection and drug resistance · 2025Article
- First case of fungal peritonitis caused byMedical mycology case reports · 2024Article
- Stability and Qualification of a Legacy Fungal Collection.Biopreservation and biobanking · 2024Article
- Evolutionary origin and population diversity of a cryptic hybrid pathogen.Nature communications · 2024Article
- What do We Know about Cryptic Aspergillosis?Microorganisms · 2024Review
- Phylogenomics reveals extensive misidentification of fungal strains from the genusMicrobiology spectrum · 2024Article
- Aflatoxin profiles of Aspergillus flavus isolates in Sudanese fungal rhinosinusitis.Medical mycology · 2024Article
- Changes in fungal taxonomy: mycological rationale and clinical implications.Clinical microbiology reviews · 2023Review
- Drug-ResistantPathogens (Basel, Switzerland) · 2023Review
- Fungi involved in rhinosinusitis in arid regions: insights from molecular identification and antifungal susceptibility.Microbiology spectrum · 2023Article
- Know the enemy and know yourself: Addressing cryptic fungal pathogens of humans and beyond.PLoS pathogens · 2023Article
94 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
In a prior study, we identified seven clinical isolates of an Aspergillus sp. that were slow to sporulate in multiple media and demonstrated decreased in vitro susceptibilities to multiple antifungals, including amphotericin B, itraconazole, voriconazole, and caspofungin. These isolates were initially considered to be variants of Aspergillus fumigatus because of differences in mitochondrial cytochrome b sequences and unique randomly amplified polymorphic DNA PCR patterns (S. A. Balajee, M. Weaver, A. Imhof, J. Gribskov, and K. A. Marr, Antimicrob. Agents Chemother. 48: 1197-1203, 2004). The present study was performed to clarify the taxonomic status of these organisms by phylogenetic analyses based on multilocus sequence typing of five genes (the beta-tubulin gene, the rodlet A gene, the salt-responsive gene, the mitochondrial cytochrome b gene, and the internal transcribed spacer regions). Results revealed that four of the seven variant isolates clustered together in a clade very distant from A. fumigatus and distinct from other members of the A. fumigatus group. This new clade, consisting of four members, was monophyletic with strong bootstrap support when the protein-encoding regions were analyzed, indicating a new species status under the phylogenetic species concept. Phenotype studies revealed that the variant isolate has smaller conidial heads with diminutive vesicles compared to A. fumigatus and is not able to survive at 48 degrees C. Our findings suggest the presence of a previously unrecognized, potentially drug-resistant Aspergillus species that we designate A. lentulus.
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