ArticleEukaryotic cell2005
Mutator-like element in the yeast Yarrowia lipolytica displays multiple alternative splicings.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Insights into the Genomic and Phenotypic Landscape of the Oleaginous YeastJournal of fungi (Basel, Switzerland) · 2023Article
- Cloning of MaizeInternational journal of molecular sciences · 2022Article
- Stable isotope and chemical inhibition analyses suggested the existence of a non-mevalonate-like pathway in the yeast Yarrowia lipolytica.Scientific reports · 2021Article
- Evolution ofMobile DNA · 2019Article
- Genome Sequence of the Oleaginous Yeast Yarrowia lipolytica H222.Microbiology resource announcements · 2019Article
- Transposition of Mutator-like transposable elements (MULEs) resembles hAT and Transib elements and V(D)J recombination.Nucleic acids research · 2017Article
- An Evolutionary Perspective on Yeast Mating-Type Switching.Genetics · 2017Review
- Functional characterization of the activeMobile DNA · 2017Article
- Sequence Assembly of Yarrowia lipolytica Strain W29/CLIB89 Shows Transposable Element Diversity.PloS one · 2016Article
- Clade- and species-specific features of genome evolution in the Saccharomycetaceae.FEMS yeast research · 2015Article
- Transposition of a rice Mutator-like element in the yeast Saccharomyces cerevisiae.The Plant cell · 2015Article
- Evolutionary dynamics of hAT DNA transposon families in Saccharomycetaceae.Genome biology and evolution · 2014Article
- Article
- Selective acquisition and retention of genomic sequences by Pack-Mutator-like elements based on guanine-cytosine content and the breadth of expression.Plant physiology · 2013Article
- Identification of an active Mutator-like element (MULE) in rice (Oryza sativa).Molecular genetics and genomics : MGG · 2012Article
- Phantom, a new subclass of Mutator DNA transposons found in insect viruses and widely distributed in animals.Genetics · 2010Article
- Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts.Genome biology · 2010Article
- Comparative genomics of protoploid Saccharomycetaceae.Genome research · 2009Article
- The protist Trichomonas vaginalis harbors multiple lineages of transcriptionally active Mutator-like elements.BMC genomics · 2009Article
- Génolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes.Nucleic acids research · 2009Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new type of DNA transposon, Mutyl, has been identified in the sequenced genome of the yeast Yarrowia lipolytica. This transposon is 7,413 bp long and carries two open reading frames (ORFs) which potentially encode proteins of 459 and 1,178 amino acids, respectively. Whereas the first ORF shows no significant homology to previously described proteins, the second ORF shows sequence similarities with various Mutator-like element (MULE)-encoded transposases, including the bacterial transposase signature sequence. Other MULE features shared by Mutyl include a zinc finger motif in the putative transposase, a 22-bp-long imperfect inverted repeat at each end, and a 9- to 10-bp duplication of its target site in the chromosome. Of the five copies of Mutyl present in the genome, one has a deletion of the first 8 bases, and the others are full length with a single base change in one element. The first potential gene of Mutyl, mutB, was shown to be expressed in exponentially growing cells. Its sequence contains a predicted intron with two 5' splice sites, a single branch point, and two 3' splice sites. Its mRNA is alternatively spliced, as judged by reverse transcription-PCR, and generates four mRNAs corresponding to protein-coding sequences of 128, 156, 161, and 190 amino acids. Of the three distinct lineages characterized in Y. lipolytica, strains from the German lineage and the French lineage do not carry Mutyl. A study of the distribution of Mutyl in strains of the French lineage evidenced a recent transposition event. Taken together, these results indicate that Mutyl is still active.
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