ArticleEukaryotic cell2005
Cryptic paraflagellar rod in endosymbiont-containing kinetoplastid protozoa.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- The cytoskeleton of pathogenic protists.Bioscience reports · 2026Review
- Endosymbiosis in trypanosomatids: the bacterium regulates the intermediate and oxidative metabolism of the host cell.mSphere · 2025Article
- Kharon Is Crucial forPathogens (Basel, Switzerland) · 2025Article
- Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes.Nature communications · 2022Article
- The Importance of Glycerophospholipid Production to the Mutualist Symbiosis of Trypanosomatids.Pathogens (Basel, Switzerland) · 2021Article
- Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells.Cell discovery · 2021Article
- Structural studies of the shortest extended synaptotagmin with only two C2 domains fromiScience · 2021Article
- Trypanin Disruption Affects the Motility and Infectivity of the ProtozoanFrontiers in cellular and infection microbiology · 2021Article
- The single flagellum ofJournal of cell science · 2020Article
- Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes.Journal of cell science · 2020Article
- Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins ofVaccines · 2020Article
- Parasite motility is critical for virulence of African trypanosomes.Scientific reports · 2018Article
- Life Cycle, Ultrastructure, and Phylogeny of New Diplonemids and Their Endosymbiotic Bacteria.mBio · 2018Article
- Expanded repertoire of kinetoplast associated proteins and unique mitochondrial DNA arrangement of symbiont-bearing trypanosomatids.PloS one · 2017Article
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- An overview on kinetoplastid paraflagellar rod.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Review
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- Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity.Eukaryotic cell · 2011Article
- Structure of Trypanosoma brucei flagellum accounts for its bihelical motion.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Cilia and flagella are central to many biological processes in a diverse range of organisms. The kinetoplastid protozoa are very appealing models for the study of flagellar function, particularly in the light of the availability of extensive trypanosomatid genome information. In addition to the highly conserved 9 + 2 axoneme, the kinetoplastid flagellum contains a characteristic paraflagellar rod structure (PFR). The PFR is necessary for full motility and provides support for metabolic regulators that may influence flagellar beating. However, there is an intriguing puzzle: one clade of endosymbiont-containing kinetoplastids apparently lack a PFR yet are as motile as species that possess a PFR and are able to attach to the invertebrate host epithelia. We investigated how these organisms are able to locomote despite the apparent lack of PFR. Here we have identified a PFR1 gene in the endosymbiont-bearing trypanosome Crithidia deanei. This gene is expressed in C. deanei and is able to partially complement a pfr1 null mutation in Leishmania mexicana cells, demonstrating that the encoded protein is functional. Careful reexamination of C. deanei flagellar ultrastructure revealed a greatly reduced PFR missed by many previous analyses. This affirms the PFR as a canonical organelle of kinetoplastids. Moreover, although PFR proteins have been conserved in evolution, primary sequence differences contribute to particular PFR morphotypes characteristic of different kinetoplastid species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.