ArticleNucleic acids research2005
Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Direct Phasing of Protein Crystals with Continuous Iterative Projection Algorithms and Refined Envelope Reconstruction.Biomolecules · 2026Article
- Divalent metal cofactors differentially modulate RadA-mediated strand invasion and exchange in Saccharolobus solfataricus.Bioscience reports · 2023Article
- Review
- Structural basis for adPEO-causing mutations in the mitochondrial TWINKLE helicase.Human molecular genetics · 2019Article
- Post-translational environmental switch of RadA activity by extein-intein interactions in protein splicing.Nucleic acids research · 2015Article
- Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.Archaea (Vancouver, B.C.) · 2014Review
- Nanobiomotors of archaeal DNA repair machineries: current research status and application potential.Cell & bioscience · 2014Review
- Structure of a filament of stacked octamers of human DMC1 recombinase.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Structure of a hexameric form of RadA recombinase from Methanococcus voltae.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- Target molecular simulations of RecA family protein filaments.International journal of molecular sciences · 2012Article
- Repair of DNA double-strand breaks following UV damage in three Sulfolobus solfataricus strains.Journal of bacteriology · 2010Article
- Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity.Journal of molecular biology · 2009Article
- Inter-subunit interactions that coordinate Rad51's activities.Nucleic acids research · 2009Article
- Article
- Article
- Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins.Nucleic acids research · 2007Article
- The Sulfolobus solfataricus radA paralogue sso0777 is DNA damage inducible and positively regulated by the Sta1 protein.Nucleic acids research · 2007Article
- Rec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydis.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Homologous recombinational repair is an essential mechanism for repair of double-strand breaks in DNA. Recombinases of the RecA-fold family play a crucial role in this process, forming filaments that utilize ATP to mediate their interactions with single- and double-stranded DNA. The recombinase molecules present in the archaea (RadA) and eukaryota (Rad51) are more closely related to each other than to their bacterial counterpart (RecA) and, as a result, RadA makes a suitable model for the eukaryotic system. The crystal structure of Sulfolobus solfataricus RadA has been solved to a resolution of 3.2 A in the absence of nucleotide analogues or DNA, revealing a narrow filamentous assembly with three molecules per helical turn. As observed in other RecA-family recombinases, each RadA molecule in the filament is linked to its neighbour via interactions of a short beta-strand with the neighbouring ATPase domain. However, despite apparent flexibility between domains, comparison with other structures indicates conservation of a number of key interactions that introduce rigidity to the system, allowing allosteric control of the filament by interaction with ATP. Additional analysis reveals that the interaction specificity of the five human Rad51 paralogues can be predicted using a simple model based on the RadA structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.