ArticleNucleic acids research2005
Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Article
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- Divergence of X-linked trans regulatory proteins and the misexpression of gene targets in sterile Drosophila pseudoobscura hybrids.BMC genomics · 2022Article
- Review
- Gene Repositioning Is Under Constraints After Evolutionary Conserved Gene Neighborhood Separate.Frontiers in genetics · 2019Article
- Intrachromosomal colocalization strengthens co-expression, co-modification and evolutionary conservation of neighboring genes.BMC genomics · 2018Article
- GC Content Heterogeneity Transition of Conserved Noncoding Sequences Occurred at the Emergence of Vertebrates.Genome biology and evolution · 2016Article
- Enhancer Sharing Promotes Neighborhoods of Transcriptional Regulation Across Eukaryotes.G3 (Bethesda, Md.) · 2016Article
- Histone modifications facilitate the coexpression of bidirectional promoters in rice.BMC genomics · 2016Article
- Global Transcriptional Profiling of Diapause and Climatic Adaptation in Drosophila melanogaster.Molecular biology and evolution · 2016Article
- Map of open and closed chromatin domains in Drosophila genome.BMC genomics · 2014Article
- Relocation facilitates the acquisition of short cis-regulatory regions that drive the expression of retrogenes during spermatogenesis in Drosophila.Molecular biology and evolution · 2014Article
- Short and long-term genome stability analysis of prokaryotic genomes.BMC genomics · 2013Article
- Uncovering the functional constraints underlying the genomic organization of the odorant-binding protein genes.Genome biology and evolution · 2013Article
- Dynamics and innovations within oomycete genomes: insights into biology, pathology, and evolution.Eukaryotic cell · 2012Review
- Article
- Transcription factories in the context of the nuclear and genome organization.Nucleic acids research · 2011Review
- Intralocus sexual conflict resolved through gene duplication.Trends in ecology & evolution · 2011Article
- Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis.BMC bioinformatics · 2011Article
- Whole-genome expression plasticity across tropical and temperate Drosophila melanogaster populations from Eastern Australia.Molecular biology and evolution · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recently, the phenomenon of clustering of co-expressed genes on chromosomes was discovered in eukaryotes. To explore the hypothesis that genes within clusters occupy shared chromatin domains, we performed a detailed analysis of transcription pattern and chromatin structure of a cluster of co-expressed genes. We found that five non-homologous genes (Crtp, Yu, CK2betates, Pros28.1B and CG13581) are expressed exclusively in Drosophila melanogaster male germ-line and form a non-interrupted cluster in the 15 kb region of chromosome 2. The cluster is surrounded by genes with broader transcription patterns. Analysis of DNase I sensitivity revealed 'open' chromatin conformation in the cluster and adjacent regions in the male germ-line cells, where all studied genes are transcribed. In contrast, in somatic tissues where the cluster genes are silent, the domain of repressed chromatin encompassed four out of five cluster genes and an adjacent non-cluster gene CG13589 that is also silent in analyzed somatic tissues. The fifth cluster gene (CG13581) appears to be excluded from the chromatin domain occupied by the other four genes. Our results suggest that extensive clustering of co-expressed genes in eukaryotic genomes does in general reflect the domain organization of chromatin, although domain borders may not exactly correspond to the margins of gene clusters.
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