ArticleNucleic acids research2005
A critical role for the Sp1-binding sites in the transforming growth factor-beta-mediated inhibition of lipoprotein lipase gene expression in macrophages.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Role of Sp1 in atherosclerosis.Molecular biology reports · 2022Review
- New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation.Cardiovascular research · 2021Review
- New Insights into the Immunobiology of Mononuclear Phagocytic Cells and Their Relevance to the Pathogenesis of Cardiovascular Diseases.Frontiers in immunology · 2017Review
- The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake.Scientific reports · 2016Article
- Article
- PDGF-D expression is down-regulated by TGFβ in fibroblasts.PloS one · 2014Article
- Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance.Frontiers in endocrinology · 2014Article
- Differential regulation of macropinocytosis in macrophages by cytokines: implications for foam cell formation and atherosclerosis.Cytokine · 2013Article
- TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2.Biochimica et biophysica acta · 2012Article
- TGF-β mediated DNA methylation in prostate cancer.Translational andrology and urology · 2012Article
- Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control study.Lipids in health and disease · 2011Article
- The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-Jun.The international journal of biochemistry & cell biology · 2011Article
- A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression.Cellular signalling · 2011Article
- The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules.BMC systems biology · 2009Article
- Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.American journal of respiratory cell and molecular biology · 2009Article
- The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3.Cellular signalling · 2008Article
- Angiotensin type 1 (AT1) and type 2 (AT2) receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac hypertrophy.Pflugers Archiv : European journal of physiology · 2007Article
- Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.Nucleic acids research · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Increasing evidence suggests that the cytokine transforming growth factor-beta (TGF-beta) inhibits the development of atherosclerosis. The lipoprotein lipase (LPL) enzyme expressed by macrophages has been implicated in the pathogenesis of atherosclerosis by stimulating the uptake of lipoprotein particles. Unfortunately, the action of TGF-beta on the expression of LPL in macrophages remains largely unclear. We show that TGF-beta inhibits LPL gene expression at the transcriptional level. Transient transfection assays reveal that the -31/+187 sequence contains the minimal TGF-beta-responsive elements. Electrophoretic mobility shift assays show that Sp1 and Sp3 interact with two regions in the -31/+187 sequence. Mutations of these Sp1/Sp3 sites abolish the TGF-beta-mediated suppression whereas multimers of the sequence impart the response to a heterologous promoter. TGF-beta has no effect on the binding or steady-state polypeptide levels of Sp1 and Sp3. These results, therefore, suggest a novel mechanism for the TGF-beta-mediated repression of LPL gene transcription that involves regulation of the action of Sp1 and Sp3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.