ArticleJournal of the American Chemical Society2005
Enhanced fluorescence cyanide detection at physiologically lethal levels: reduced ICT-based signal transduction.
Article in Journal of the American Chemical Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 390 citations in OpenAlex.
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- A new phenothiazine-based selective visual and fluorescent sensor for cyanide.BMC chemistry · 2020Article
- Determination of Cyanide in Water and Food Samples Using an Efficient Naphthalene-Based Ratiometric Fluorescent Probe.ACS omega · 2019Article
- Current Advancements in Transdermal Biosensing and Targeted Drug Delivery.Sensors (Basel, Switzerland) · 2019Review
- Selective "Turn-On" Fluorescent Sensor for Cyanide in Aqueous Environment and Test Strips.Journal of fluorescence · 2019Article
- Substituted 2-Aminobenzothiazoles Salicylidenes Synthesis and Characterization as Cyanide Sensors in Aqueous Medium.Sensors (Basel, Switzerland) · 2018Article
- A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons.Journal of the American Chemical Society · 2018Article
- A Biocompatible Colorimetric Triphenylamine- Dicyanovinyl Conjugated Fluorescent Probe for Selective and Sensitive Detection of Cyanide Ion in Aqueous Media and Living Cells.Sensors (Basel, Switzerland) · 2017Article
- A Simple Colorimetric Chemosensor for Naked Eye Detection of Cyanide Ion.Journal of fluorescence · 2016Article
- Ratiometric and colorimetric near-infrared sensors for multi-channel detection of cyanide ion and their application to measure β-glucosidase.Scientific reports · 2015Article
- Zinc oxide nanomaterials for biomedical fluorescence detection.Journal of nanoscience and nanotechnology · 2014Review
- A highly efficient dinuclear Cu(II) chemosensor for colorimetric and fluorescent detection of cyanide in water.RSC advances · 2014Article
- A selective spectrofluorometric determination of micromolar level of cyanide in water using naphthoquinone imidazole boronic-based sensors and a surfactant cationic CTAB micellar system.Journal of fluorescence · 2011Article
- Donor-acceptor substituted phenylethynyltriphenylenes - excited state intramolecular charge transfer, solvatochromic absorption and fluorescence emission.Beilstein journal of organic chemistry · 2010Article
- Carbohydrate recognition by boronolectins, small molecules, and lectins.Medicinal research reviews · 2010Review
- Strapped calix[4]pyrroles bearing a 1,3-indanedione at a beta-pyrrolic position: chemodosimeters for the cyanide anion.Organic letters · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Three water-soluble fluorescent probes have been specifically designed to determine free cyanide concentrations up to physiologically lethal levels, >20 microM. The probes have been designed in such a way as to afford many notable sensing features, which render them unique with regard to signal transduction, photophysical characteristics, and their application to physiological cyanide determination and safeguard. The probes are readily able to reversibly bind free aqueous cyanide with dissociation constants around 4 microM3. Subsequent cyanide binding modulates the intramolecular charge transfer within the probes, a change in the electronic properties within the probes, resulting in enhanced fluorescence optical signals as a function of increased solution cyanide concentration. The ground-state chelation with cyanide produces wavelength shifts, which also enable the probes to sense cyanide in both an excitation and emission ratiometric manner, in addition to enhanced fluorescence signaling. This has enabled a generic cyanide sensing platform to be realized that is not dependent on fluorescent probe concentration, probe photodegradation, or fluctuations in the intensity of any employed excitation sources, ideal for remote cyanide sensing applications. Further, the >600 nm fluorescence emission of the probes potentially allows for enhanced fluorescence ratiometric cyanide sensing in the optical window of tissues and blood, facilitating their use for the transdermal monitoring of cyanide for mammalian safeguard or postmortem in fire victims, both areas of active research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.