ArticleWorld journal of gastroenterology2005
Transforming growth factor beta can be a parameter of aggressiveness of pT1 colorectal cancer.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-analysis of histopathological features of primary colorectal cancers that predict lymph node metastases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Pooled it
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- Review
- Effects of CDX2 on prognosis and chemotherapy responsiveness in mismatch repair-deficient colorectal cancer.BJS open · 2018Article
- Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer.Scientific reports · 2016Article
- Microenvironmental interactions and expression of molecular markers associated with epithelial-to-mesenchymal transition in colorectal carcinoma.International journal of clinical and experimental pathology · 2015Article
- The density of macrophages in colorectal cancer is inversely correlated to TGF-β1 expression and patients' survival.Journal of molecular histology · 2013Article
- Prognostic value of tumor progression-related gene expression in colorectal cancer patients.Journal of cancer research and clinical oncology · 2012Article
- NS398 induces apoptosis in non-small cell lung cancer cells.Journal of cancer research and clinical oncology · 2012Article
- Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget.Oncotarget · 2010Review
- Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas.Oncogene · 2010Article
- Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer.International journal of colorectal disease · 2010Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the significance of transforming growth factor beta (TGF beta) expression, in correlation with histopathological parameters, at the front of invasion in T1 colorectal cancer (CRC) and presence of metastases.
methodsTGF beta immunohistochemical expression was studied in 34 specimens of colorectal adenocarcinomas (pT1). A three-step avidin-biotinylated immuno-peroxidase (ABCu-NCL) staining technique was performed on 4-mum paraffin-embedded tissue sections with a monoclonal antibody to TGF beta (Novocastra, NCL-TGFB, clone TGFB 17, dilution 1:40).
resultsSeventeen (50%) out of 34 lesions were positive for TGF beta expression. The TGF beta-positive rate in patients with vascular invasion was significantly higher than in those without vascular invasion (11/14 cases, P<0.01, P = 0.005). The TGF beta-positive rate was observed in 91.7% of patients with presence of tumor budding at the front of invasion (11/12 cases, P<0.01, P = 0.0003). A statistically significant correlation was found between the presence of lymph node metastases and positive expression of TGF beta (14/16 cases, P<0.01, P = 0.0001). We also observed that the TGF beta-positive rates in groups with distant and non-distant metastases were 92.8% and 20% respectively, and a significant correlation between TGF beta expression and distant metastasis was shown (P<0.01, P = 0.00003).
conclusionThe evaluation of TGF beta expression of protein in association with histological parameters can be used as a parameter of the aggressiveness of pT1 CRC.
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