ArticleJournal of materials science. Materials in medicine2005
Microneedles coated with porous calcium phosphate ceramics: effective vehicles for transdermal delivery of solid trehalose.
Article in Journal of materials science. Materials in medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 64 citations in OpenAlex.
- Physiological impact of nanoporous acupuncture needles: Laser Doppler perfusion imaging in healthy volunteers.PloS one · 2019Trial
- 3D printing redefines microneedle fabrication for transdermal drug delivery.Biomedical engineering letters · 2024Article
- The Effect of Trehalose Coating for Magnetite Nanoparticles on Stability of Egg White Lysozyme.International journal of molecular sciences · 2022Article
- Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases.Journal of molecular neuroscience : MN · 2022Review
- Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery.Scientific reports · 2022Article
- Synthesis, Characterization, Anti-Cancer Analysis of SrNanomaterials (Basel, Switzerland) · 2021Article
- Functionalized microneedles for continuous glucose monitoring.Nano convergence · 2018Review
- Recent advances of controlled drug delivery using microfluidic platforms.Advanced drug delivery reviews · 2018Review
- Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery.PloS one · 2017Article
- Hierarchical Micro/Nano-Porous Acupuncture Needles Offering Enhanced Therapeutic Properties.Scientific reports · 2016Article
- Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays.Drug delivery and translational research · 2015Review
- Laser-engineered dissolving microneedles for active transdermal delivery of nadroparin calcium.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2012Article
- pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release.International journal of nanomedicine · 2012Article
- Microneedle-based vaccines.Current topics in microbiology and immunology · 2009Review
- Controlled size and morphology of EDTMP-doped hydroxyapatite nanoparticles as model for 153Samarium-EDTMP doping.Journal of materials science. Materials in medicine · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trehalose (alpha-D-glucopyranosyl-alpha-D-glucopyranoside) is recognized as a promising fast-dissolving solid reservoir capable of stabilizing the native structure of proteins and suitable for loading with a wide variety of bioactive substances. Currently, there is a growing interest in developing cost-effective methods for immobilizing solid trehalose on arrays of microneedles for delivering protein-based and DNA-based vaccine to the epidermis. In the present work, micro-porous calcium phosphate coatings were used to provide a biocompatible interface with a large surface area for the effective immobilization of trehalose on microneedles. Calcium phosphate coatings with varying degrees of porosity were electrochemically synthesized on the tips of stainless steel acupuncture needles and loaded with solid trehalose. Skin experiments were designed to determine the ability of micro-porous calcium phosphate coatings to deliver solid trehalose into epidermis without breaking during insertion. The mechanical performance of the coatings was assessed by inserting the tips of the coated needles into human skin to an average depth of 100-300 microm and then removing them for analysis by scanning electron microscopy. Microporous calcium phosphate coatings loaded with trehalose effectively breached the stratum corneum and allowed direct access to the epidermis without breaking and without stimulating nerves in deeper tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.