Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2005
Home-based resistance training improves femoral bone mineral density in women on hormone therapy.
Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Facilitators and barriers to exercise adherence in patients with osteopenia and osteoporosis: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Progressive resistance strength training for improving physical function in older adults.The Cochrane database of systematic reviews · 2009Pooled it
- Exercise for Smoking Cessation in Postmenopausal Women: A Randomized, Controlled Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Trial
- Delivery and outcomes of a yearlong home exercise program after hip fracture: a randomized controlled trial.Archives of internal medicine · 2011Trial
- Effect of office-based brief high-impact exercise on bone mineral density in healthy premenopausal women: the Sendai Bone Health Concept Study.Journal of bone and mineral metabolism · 2010Trial
- Physical activity and health-related quality of life among postmenopausal women with breast cancer treated with aromatase inhibitors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health sarcopenia project.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Grip strength cutpoints for the identification of clinically relevant weakness.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- An evidence-based comparison of operational criteria for the presence of sarcopenia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- The role of osteocalcin in human glucose metabolism: marker or mediator?Nature reviews. Endocrinology · 2013Review
- Gender differences in anthropometric predictors of physical performance in older adults.Gender medicine · 2012Article
- Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study.Nutrition & metabolism · 2011Article
- Post-partum sacral fracture associated with heparin treatment.Clinical rheumatology · 2008Article
- An aerobic weight-loaded pilot exercise intervention for breast cancer survivors: bone remodeling and body composition outcomes.Biological research for nursing · 2008Article
- Femoral bone mineral density in patients with heart failure.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2006Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This study tested whether moderate resistance training would improve femoral bone mineral density (BMD) in long-term users of hormone therapy with low BMD. The study was a 2-year randomized, controlled, trial (RCT) of moderate resistance training of either the lower extremity or the upper extremity. Eighty-five women participated in a 6-month observation period. The setting was center-based and home-based training. The participants were 189 women aged 59-78 years, with total femur T-scores from -0.8 to -2.8 and on hormone therapy (HT) for a minimum of 2 years (mean 11.8 years); 153 completed the trial. Lower extremity training used weight belts (mean 7.8 kg) in step-ups and chair rises; upper extremity training used elastic bands and dumbbells. Measurements were BMD and body composition [dual-energy X-ray absorptiometry (DXA)], bone turnover markers. Total femoral BMD showed a downward trend during the observation period: 0.35%+/-0.18% (P=0.14). The response to training was similar in the upper and lower groups in the primary outcomes. At 2 years, total femoral BMD increased 1.5% (95% CI 0.8%-2.2%) in the lower group and 1.8% (95% CI 1.1%-2.5%) in the upper group. Trochanter BMD increased 2.4% (95% CI 1.3%-3.5%) in the lower group and 2.5% (95% CI 1.4%-3.6%) in the upper group (for both analyses time effect P<0.001). At 1 year, a bone resorption marker (C-telopeptide) decreased 9% (P=0.04). Bone formation markers, bone-specific alkaline phosphatase, decreased 5% (P<0.001), and N-terminal type I procollagen peptide decreased 7% (P=0.01). Body composition (percent lean and percent body fat) was maintained in both groups. We concluded that long-term moderate resistance training reversed bone loss, decreased bone turnover, increased femur BMD, and maintained body composition. The similarity of response in upper and lower groups supports a systemic response rather than a site-specific response to moderate resistance training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.