ArticleProceedings of the National Academy of Sciences of the United States of America2005
The protooncogene MYC can break B cell tolerance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- A role for IRF8 in B cell anergy.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M.The Journal of allergy and clinical immunology · 2012Article
- iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma.PloS one · 2012Article
- The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.Molecular immunology · 2011Article
- B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma.Neoplasia (New York, N.Y.) · 2011Article
- IRF4 is a suppressor of c-Myc induced B cell leukemia.PloS one · 2011Article
- SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling.Respiratory research · 2010Article
- Article
- Article
- B-cell receptor signaling in the genesis and maintenance of B-cell lymphoma.Future oncology (London, England) · 2008Review
- The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas.PLoS biology · 2008Article
- Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas.Molecular cancer · 2008Article
- The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.The Journal of experimental medicine · 2008Article
- Understanding B-cell tolerance through the use of immunoglobulin transgenic models.Immunologic research · 2008Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The protooncogene MYC has been implicated in both the proliferation and programmed cell death of lymphoid cells, and in the genesis of lymphoid tumors. Here, we report that overexpression of MYC, as found in many lymphomas, can break immune tolerance. Mice that would otherwise be tolerant to a transgenic autoantigen mounted an immune response to the antigen if MYC was vigorously expressed in the B cell lineage. The responsive B cells converted to an activated phenotype and produced copious amounts of autoantibody that engendered immune complex disease of the kidney. MYC was required to both establish and maintain the breach of tolerance. These effects may be due to the ability of MYC to serve as a surrogate for cytokines. We found that the gene could mimic the effects of cytokines on both B cell proliferation and survival and, indeed, was required for those effects. These findings demonstrate a critical role for MYC in the response of B cells to antigen and expand the potential contributions of MYC to the genesis of lymphomas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.