ArticleProceedings of the National Academy of Sciences of the United States of America2005
Origin and evolution of the chicken leukocyte receptor complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Immunoglobulin-like receptors and the generation of innate immune memory.Immunogenetics · 2022Review
- Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022Review
- Review
- The Genomic Organization of theFrontiers in immunology · 2021Review
- Bi-Functional Chicken Immunoglobulin-Like Receptors With a Single Extracellular Domain (ChIR-AB1): Potential Framework Genes Among a Relatively Stable Number of Genes Per Haplotype.Frontiers in immunology · 2019Article
- Defense genes missing from the flight division.Developmental and comparative immunology · 2013Review
- The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.Genome biology · 2013Article
- "Orphan" retrogenes in the human genome.Molecular biology and evolution · 2013Article
- Rapid evolution of Beta-keratin genes contribute to phenotypic differences that distinguish turtles and birds from other reptiles.Genome biology and evolution · 2013Article
- Characterisation of bovine leukocyte Ig-like receptors.PloS one · 2012Article
- The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities.Immunogenetics · 2011Review
- The amphibians Xenopus laevis and Silurana tropicalis possess a family of activating KIR-related Immunoglobulin-like receptors.Developmental and comparative immunology · 2010Article
- The crystal structure of CHIR-AB1: a primordial avian classical Fc receptor.Journal of molecular biology · 2008Article
- Housekeeping and tissue-specific genes in mouse tissues.BMC genomics · 2007Article
- Channel catfish leukocyte immune-type receptors contain a putative MHC class I binding site.Immunogenetics · 2007Article
- A novel family of diversified immunoregulatory receptors in teleosts is homologous to both mammalian Fc receptors and molecules encoded within the leukocyte receptor complex.Immunogenetics · 2006Article
- Ancient divergence of a complex family of immune-type receptor genes.Immunogenetics · 2006Article
- The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci.PLoS genetics · 2006Article
- Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation.Nucleic acids research · 2006Article
- Comparative genomics of natural killer cell receptor gene clusters.PLoS genetics · 2005Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In mammals, the cell surface receptors encoded by the leukocyte receptor complex (LRC) regulate the activity of T lymphocytes and B lymphocytes, as well as that of natural killer cells, and thus provide protection against pathogens and parasites. The chicken genome encodes many Ig-like receptors that are homologous to the LRC receptors. The chicken Ig-like receptor (CHIR) genes are members of a large monophyletic gene family and are organized into genomic clusters, which are in conserved synteny with the mammalian LRC. One-third of CHIR genes encode polypeptide molecules that contain both activating and inhibitory motifs. These genes are present in different phylogenetic groups, suggesting that the primordial CHIR gene could have encoded both types of motifs in a single molecule. In contrast to the mammalian LRC genes, the CHIR genes with similar function (inhibition or activation) are evolutionarily closely related. We propose that, in addition to recombination, single nucleotide substitutions played an important role in the generation of receptors with different functions. Structural models and amino acid analyses of the CHIR proteins reveal the presence of different types of Ig-like domains in the same phylogenetic groups, as well as sharing of conserved residues and conserved changes of residues between different CHIR groups and between CHIRs and LRCs. Our data support the notion that the CHIR gene clusters are regions homologous to the mammalian LRC gene cluster and favor a model of evolution by repeated processes of birth and death (expansion-contraction) of the Ig-like receptor genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.