ArticleClinical and diagnostic laboratory immunology2005
Evaluation of three immunoassay kits for rapid detection of influenza virus A and B.
Article in Clinical and diagnostic laboratory immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 88 citations in OpenAlex.
- ERS/ESCMID state-of-the-science statement on the role of rapid diagnostic tests for the diagnosis and management of community-acquired lower respiratory tract infections.The European respiratory journal · 2026Review
- Broadly neutralizing monoclonal antibodies against influenza A viruses: current insights and future directions.Frontiers in microbiology · 2025Review
- Recent advances in lab-on-a-chip technologies for viral diagnosis.Biosensors & bioelectronics · 2020Review
- Laboratory Diagnosis of Respiratory Tract Infections in Children - the State of the Art.Frontiers in microbiology · 2018Review
- Performance of the Quidel Sofia rapid influenza diagnostic test during the 2012-2013 and 2013-2014 influenza seasons.Influenza and other respiratory viruses · 2016Article
- Paper-Based RNA Extraction, in Situ Isothermal Amplification, and Lateral Flow Detection for Low-Cost, Rapid Diagnosis of Influenza A (H1N1) from Clinical Specimens.Analytical chemistry · 2015Article
- Comparison of the BD Veritor System for Flu A+B with the Alere BinaxNOW influenza A&B card for detection of influenza A and B viruses in respiratory specimens from pediatric patients.Journal of clinical microbiology · 2014Article
- Analytical detection of influenza A(H3N2)v and other A variant viruses from the USA by rapid influenza diagnostic tests.Influenza and other respiratory viruses · 2013Article
- Evaluation of the ESPLINE® Influenza A & B-N assay for the detection of influenza A and B in nasopharyngeal aspirates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Comparison of polyurethane foam to nylon flocked swabs for collection of secretions from the anterior nares in performance of a rapid influenza virus antigen test in a pediatric emergency department.Journal of clinical microbiology · 2010Article
- Estimating sensitivity of laboratory testing for influenza in Canada through modelling.PloS one · 2009Article
- Near-patient assays for diagnosis of influenza virus infection in adult patients.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2009Article
- Multiplex assay for simultaneously typing and subtyping influenza viruses by use of an electronic microarray.Journal of clinical microbiology · 2009Article
- Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses.Journal of medical virology · 2009Article
- Micro- and nanotechnology for viral detection.Analytical and bioanalytical chemistry · 2009Review
- Optimal sampling sites and methods for detection of pathogens possibly causing community-acquired lower respiratory tract infections.Journal of clinical microbiology · 2009Review
- Analytical and clinical sensitivity of the 3M rapid detection influenza A+B assay.Journal of clinical microbiology · 2008Article
- Role of influenza and other respiratory viruses in admissions of adults to Canadian hospitals.Influenza and other respiratory viruses · 2008Article
- [Respiratory viruses: old and new. Review of diagnostic methods].Enfermedades infecciosas y microbiologia clinica · 2007Article
- Real-time RT-PCR assays for type and subtype detection of influenza A and B viruses.Influenza and other respiratory viruses · 2007Article
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2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza causes high morbidity and mortality in very young and elderly individuals, which can be controlled with antivirals and/or vaccines. The success of therapeutic measures is predicated on the rapid and precise diagnosis of the infection. We compared three rapid influenza immunoassay (RIIA) kits for the diagnosis of influenza virus A and B using 178 respiratory specimens submitted for routine testing. BD Directigen Flu A+B (Directigen), Directigen EZ Flu A+B (EZ), and NOW Flu A NOW Flu B (NOW; Binax) tests had comparable combined influenza virus A and B specificities, varying from 94 to 98%. In contrast, the sensitivity of EZ was significantly lower (39%) than that of NOW (76%) and marginally lower than that of Directigen (56%). The differences in sensitivity were most evident in patients who were >9 years old (Directigen, 53%; EZ, 32%; and NOW, 69%). Among specimens, bronchoalveolar lavage fluids yielded the most discrepant results, with sensitivities varying from 0 (EZ) to 100% (NOW), followed by nasopharyngeal swabs (sensitivities of 27 to 100%) and nasal washes (50 to 81%). The Directigen kit format allowed for faster completion but more cumbersome performance and more difficult interpretation compared with the other two kits. Overall, NOW provided the most accurate diagnoses and had user-friendly technical characteristics. However, the low overall sensitivity of the RIIAs indicates that these can be used as screening tools only.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.