ArticleOncogene2005
Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Novel neuroendocrine role of γ-aminobutyric acid and gastrin-releasing peptide in the host response to influenza infection.Mucosal immunology · 2023Article
- A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.Frontiers in immunology · 2022Review
- Review
- Neuromedin B modulates phosphate-induced vascular calcification.BMB reports · 2021Article
- Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury.Frontiers in immunology · 2021Review
- New Insights into the Stereochemical Requirements of the Bombesin BB1 Receptor Antagonists Binding.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification.Cells · 2020Article
- Comparative Transcriptome Analysis During the Seven Developmental Stages of Channel Catfish (Frontiers in genetics · 2020Article
- Chronic itch development in sensory neurons requires BRAF signaling pathways.The Journal of clinical investigation · 2013Article
- Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells.Autophagy · 2013Article
- Autophagy mediates paracrine regulation of vascular endothelial cells.Laboratory investigation; a journal of technical methods and pathology · 2013Article
- Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide.The American journal of pathology · 2013Article
- Development of hypoxia enhanced 111In-labeled Bombesin conjugates: design, synthesis, and in vitro evaluation in PC-3 human prostate cancer.Bioconjugate chemistry · 2012Article
- Article
- Vaccines targeting the neovasculature of tumors.Vascular cell · 2011Article
- Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Non-peptide small molecule regulators of lymphangiogenesis.Lymphatic research and biology · 2009Article
- Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone.Biology of reproduction · 2008Article
- Genetic changes in small cell lung carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2008Review
- Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia.American journal of respiratory and critical care medicine · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Angiogenesis is becoming a major target for antitumor therapies, and identifying new angiogenic factors and their specific inhibitors may provide new avenues for tumor management. Here we identify gastrin-releasing peptide (GRP) as a new angiogenic molecule that is secreted by tumors and acts directly upon GRP receptors in the endothelial cells. Addition of GRP increases endothelial cell migration and cord formation in vitro, and induces angiogenesis in an in vivo assay. We have recently identified a small molecule GRP blocker, compound 77427. This inhibitor significantly reduced endothelial cell cord formation in vitro and angiogenesis in vivo. Conversely, when applied to VEGF-induced angiogenesis, the small molecule did not have any effect, demonstrating its specificity. Furthermore, this GRP blocker was able to reduce lung tumor cell growth in vitro as demonstrated by MTT and clonogenic assays. When applied to a xenograft model with lung cancer cells, compound 77427 reduced tumor volume to undetectable sizes, although when the treatment was suspended, tumors began to grow again at normal rates. Our collective observations indicate that GRP is a new angiogenic peptide and that its inhibition offers an attractive tool to reduce tumor burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.