Trial reportMedical oncology (Northwood, London, England)2005
Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: results of a controlled clinical trial.
Trial report in Medical oncology (Northwood, London, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Primary Gastrointestinal Non-Hodgkin's Lymphoma of the Small and Large Intestines: a Systematic Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Pooled it
- Surgical treatment of primitive gastro-intestinal lymphomas: a systematic review.World journal of surgical oncology · 2011Pooled it
- Is there role of additional chemotherapy after definitive local treatment for stage I/II marginal zone lymphoma?: Consortium for Improving Survival of Lymphoma (CISL) study.International journal of hematology · 2015Trial
- A phase II study of bortezomib in patients with MALT lymphoma.Haematologica · 2009Trial
- Surgery and chemotherapy versus chemotherapy as treatment of high-grade MALT gastric lymphoma.Medical oncology (Northwood, London, England) · 2006Trial
- Should All Patients With Stage IE Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Receive Antibiotic Eradication Therapy forJCO oncology practice · 2024Article
- Treatment of indolent lymphoma.Blood research · 2022Review
- Review
- Radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma.World journal of gastrointestinal oncology · 2021Review
- How do we sequence therapy for marginal zone lymphomas?Hematology. American Society of Hematology. Education Program · 2020Review
- Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin's Lymphoma of the Duodenum: A SEER Database Analysis.Canadian journal of gastroenterology & hepatology · 2020Article
- Outcomes After Reduced-Dose Intensity Modulated Radiation Therapy for Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma.International journal of radiation oncology, biology, physics · 2019Article
- Radiotherapy for mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum: a case report.Clinical journal of gastroenterology · 2017Article
- Chemoimmunotherapy for Mucosa-Associated Lymphoid Tissue-Type Lymphoma: A Review of the Literature.The oncologist · 2015Review
- Limited role of bone marrow aspiration and biopsy in the initial staging work-up of gastric mucosa-associated lymphoid tissue lymphoma in Korea.Gut and liver · 2014Article
- Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas.World journal of gastroenterology · 2014Review
- Treatment of gastric MALT lymphoma with a focus on Helicobacter pylori eradication.International journal of hematology · 2013Review
- Comparative outcomes of oncologic therapy in gastric extranodal marginal zone (MALT) lymphoma: analysis of the SEER-Medicare database.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- Primary gastrointestinal non-Hodgkin's lymphoma: clinicopathological and prognostic analysis.Medical oncology (Northwood, London, England) · 2010Article
- Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management.Annals of oncology : official journal of the European Society for Medical Oncology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of patients with early stage gastric mucosa-associated lymphoid tissue (MALT) remains undefined. We began a controlled clinical trial to evaluate efficacy and toxicity of the most common therapies. Two hundred and forty-one patients with gastric low-grade MALT lymphoma in early stage (IE and IIE) were randomized to surgery (80 cases), radiotherapy (78 cases), and chemotherapy (83 cases). With a median follow-up of 7.5 yr, actuarial curves at 10 yr showed that event-free survival was 52% in patients treated with surgery, 52% in radiotherapy arm, and 87% in the chemotherapy group (p < 0.01). However, overall survival did not showed any statistical differences: 80%, 75% and 87%, respectively (p = 0.4). Acute and late toxicities were mild. No death-related treatments were observed. No clear differences were observed between the most common therapies in patients with primary gastric MALT lymphoma in early stages, probably because this type of lymphoma has an high response rate to salvage treatment after failure to local treatment (surgery and radiotherapy). Thus considered, chemotherapy alone is an effective and safe therapeutic approach in this setting of patients. Surgery or radiotherapy will be reserved to patients that are not candidates for chemotherapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.