ArticleJournal of clinical microbiology2005
Sequence analysis of the msp4 gene of Anaplasma phagocytophilum strains.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Immuno-Informatics Design of Multi-Epitope Vaccine Candidate AgainstHealth science reports · 2026Article
- Molecular Characterization and Prevalence of Anaplasma ovis and Anaplasma phagocytophilum in Goat Population in Siirt Province From Türkiye.Veterinary medicine and science · 2026Article
- Zoonotic Pathogens inPathogens (Basel, Switzerland) · 2026Article
- Molecular detection and characterization ofInternational journal for parasitology. Parasites and wildlife · 2025Article
- First molecular detection Anaplasma phagocytophilum in sheep in Brazil.Veterinary research communications · 2025Article
- Review of Molecular Tools Used in Diagnosis ofAnimals : an open access journal from MDPI · 2025Review
- Surveillance of tick-borne pathogens present in ticks (Acari: Ixodidae) removed from companion animals in Louisiana, USA.Journal of medical entomology · 2025Article
- Molecular epidemiology and genetic diversity of Anaplasma and Theileria spp. in Pakistani sheep.PloS one · 2025Article
- Host-pathogen associations inferred from bloodmeal analyses ofApplied and environmental microbiology · 2024Article
- Preparing Collared Peccary (Pathogens (Basel, Switzerland) · 2024Article
- Molecular Detection of Tick-Borne Pathogens in Kumasi: With a First Report of Zoonotic Pathogens in Abattoir Workers.BioMed research international · 2024Article
- Genomic analyses indicate the North American Ap-ha variant of the tick-vectored bacterium Anaplasma phagocytophilum was introduced from Europe.Parasites & vectors · 2023Article
- Host-pathogen associations revealed by genotyping of European strains of Anaplasma phagocytophilum to describe natural endemic cycles.Parasites & vectors · 2023Article
- Development of a Syndromic Molecular Diagnostic Assay for Tick-Borne Pathogens Using Barcoded Magnetic Bead Technology.Microbiology spectrum · 2023Article
- Molecular identification ofIranian journal of microbiology · 2023Article
- Associations of Anaplasma phagocytophilum Bacteria Variants in Ixodes scapularis Ticks and Humans, New York, USA.Emerging infectious diseases · 2023Article
- Temporal Dynamics ofMicroorganisms · 2023Article
- The first molecular identification and phylogenetic analysis of tick-borne pathogens in captive wild animals from Lohi Bher zoo, Pakistan.Parasitology research · 2022Article
- Experimental Infection of Mice and Ticks with the Human Isolate ofPathogens (Basel, Switzerland) · 2022Article
- Exploration and comparison of bacterial communities present in bovine faeces, milk and blood using 16S rRNA metagenomic sequencing.PloS one · 2022Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The causative agent of human granulocytic ehrlichiosis was recently reclassified as Anaplasma phagocytophilum, unifying previously described bacteria that cause disease in humans, horses, dogs, and ruminants. For the characterization of genetic heterogeneity in this species, the homologue of Anaplasma marginale major surface protein 4 gene (msp4) was identified, and the coding region was PCR amplified and sequenced from a variety of sources, including 50 samples from the United States, Germany, Poland, Norway, Italy, and Switzerland and 4 samples of A. phagocytophilum-like organisms obtained from white-tailed deer in the United States. Sequence variation between strains of A. phagocytophilum (90 to 100% identity at the nucleotide level and 92 to 100% similarity at the protein level) was higher than in A. marginale. Phylogenetic analyses of msp4 sequences did not provide phylogeographic information but did differentiate strains of A. phagocytophilum obtained from ruminants from those obtained from humans, dogs, and horses. The sequence analysis of the recently discovered A. phagocytophilum msp2 gene corroborated these results. The results reported here suggest that although A. phagocytophilum-like organisms from white-tailed deer may be closely related to A. phagocytophilum, they could be more diverse. These results suggest that A. phagocytophilum strains from ruminants could share some common characteristics, including reservoirs and pathogenicity, which may be different from strains that infect humans.
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