Evidence map›Paper›PMID 15750098›Full record

ArticleJournal of clinical microbiology2005

Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in Europe.

Ralf René Reinert, Adrian Ringelstein, Mark van der Linden, Murat Yücel Cil, Adnan Al-Lahham, Franz-Josef Schmitz

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
  2. Streptococcal peptides and their roles in host-microbe interactions.Frontiers in cellular and infection microbiology · 2023
    Review
  3. Article
  4. Article
  5. The Emergence of InvasiveFrontiers in microbiology · 2021
    Article
  6. Article
  7. Synergistic Antimicrobial Effects of CefabronchinEuropean journal of microbiology & immunology · 2019
    Article
  8. Trends in Antimicrobial Drug Resistance ofAntibiotics (Basel, Switzerland) · 2019
    Article
  9. Article
  10. Diversity of MosaicAntimicrobial agents and chemotherapy · 2017
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Antibiotic resistance amongst healthcare-associated pathogens in China.International journal of antimicrobial agents · 2012
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ralf René ReinertInstitute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, Aachen, Germany. Reinert@rwth-aachen.de
Adrian Ringelstein
Mark van der Linden
Murat Yücel Cil
Adnan Al-Lahham
Franz-Josef Schmitz
Institute of Medical Microbiology and Hygiene · DEUniversitätsklinikum Aachen · DEUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In many European countries, the level of pneumococcal resistance to macrolides has now passed the level of resistance to penicillin G. A total of 82 erythromycin A-resistant isolates of Streptococcus pneumoniae were collected by 11 laboratories in seven European countries. All of the isolates were tested for antimicrobial susceptibility, analyzed for clonal relatedness by multilocus sequence typing, and characterized for macrolide resistance genotypes. The prevalence of the macrolide resistance genotypes varied substantially between countries. In France (87.5% of all strains), Spain (77.3%), Switzerland (80%), and Poland (100%), strains were predominantly erm(B) positive, whereas higher levels of mef(A)-positive strains were reported from Greece (100%) and Germany (33.3%). Macrolide resistance was caused by the oligoclonal spread of some multilocus sequence types, but significant differences in clonal distribution were noted between France and Spain, countries from which high levels of macrolide resistance have been reported. Overall, sequence type 81 (Spain23F-1 clone) was by far the most widespread. The mainly erm(B)-positive serotype 14 clone (sequence type 143), first reported in Poland in the mid-1990s, is now widespread in France.

Indexed as

Bacterial Typing TechniquesDrug Resistance, BacterialErythromycinGenotypeHumansMicrobial Sensitivity TestsStreptococcus pneumoniaeErythromycin

Identifiers

PMID15750098
PMCPMC1081259
OpenAlexW2099075333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.