ArticleProceedings of the National Academy of Sciences of the United States of America2005
Transcriptional network underlying Caenorhabditis elegans vulval development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- The Pax transcription factor EGL-38 links EGFR signaling to assembly of a cell type-specific apical extracellular matrix in the Caenorhabditis elegans vulva.Developmental biology · 2025Article
- The Pax transcription factor EGL-38 links EGFR signaling to assembly of a cell-type specific apical extracellular matrix in thebioRxiv : the preprint server for biology · 2024Article
- A neural network-based model framework for cell-fate decisions and development.Communications biology · 2024Article
- Article
- Heterosis of fitness and phenotypic variance in the evolution of a diploid gene regulatory network.PNAS nexus · 2022Article
- Identifying the Caenorhabditis elegans vulval transcriptome.G3 (Bethesda, Md.) · 2022Article
- Article
- Article
- The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning.Journal of developmental biology · 2018Review
- Morphologically defined sub-stages of C. elegans vulval development in the fourth larval stage.BMC developmental biology · 2015Article
- Multicolor labeling in developmental gene regulatory network analysis.Methods in molecular biology (Clifton, N.J.) · 2014Article
- The co-regulation mechanism of transcription factors in the human gene regulatory network.Nucleic acids research · 2012Article
- Article
- A novel candidate cis-regulatory motif pair in the promoters of germline and oogenesis genes in C. elegans.Genome research · 2012Article
- A novel unbiased measure for motif co-occurrence predicts combinatorial regulation of transcription.BMC genomics · 2012Article
- The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.Developmental biology · 2011Article
- Profiling a Caenorhabditis elegans behavioral parametric dataset with a supervised K-means clustering algorithm identifies genetic networks regulating locomotion.Journal of neuroscience methods · 2011Article
- Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans.Developmental biology · 2010Article
- C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.Developmental biology · 2010Article
- Rapid sequence evolution of transcription factors controlling neuron differentiation in Caenorhabditis.Molecular biology and evolution · 2009Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression of cell-type-specific genes is regulated. Ras and Wnt signaling pathways play major roles in generating the spatial pattern of cell types and regulate gene expression through a network of transcription factors. One transcription factor (lin-29) primarily controls the temporal expression pattern. Other transcription factors (lin-11, cog-1, and egl-38) act in combination to control cell-type-specific gene expression. The complexity of the network arises in part because of the dynamic nature of gene expression, in part because of the presence of seven cell types, and also because there are multiple regulatory paths for gene expression within each cell type.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.