ArticleBMC gastroenterology2005
Elevated creatine kinase activity in primary hepatocellular carcinoma.
Article in BMC gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- HIF-2α induction in de novo lipogenesis in metabolic dysfunction-associated steatohepatitis is dependent on IL-21 signaling.The Journal of biological chemistry · 2026Article
- Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting.Molecular metabolism · 2025Article
- Elevated Creatine Kinase as a Marker for Aggressive GI Malignancy.Journal of community hospital internal medicine perspectives · 2025Article
- Evaluation of creatine kinase (CK)-MB to total CK ratio as a diagnostic biomarker for primary tumors and metastasis screening.Practical laboratory medicine · 2023Article
- Nutrient Density and Microbial Safety of Open-Air-Dried Beef Meat and Its Biochemical and Organ Histopathology Effects in Albino Rats: A Promising Ingredient for Complementary Food Formulation.International journal of food science · 2023Article
- Metabolic reservoir cycles in cancer.Seminars in cancer biology · 2022Review
- Elevation in creatine kinase isoenzyme-MM associated with hepatocellular carcinoma: a case report and review of literature.Clinical journal of gastroenterology · 2022Review
- Extracellular creatine kinase may modulate purinergic signalling.Purinergic signalling · 2020Review
- Ultra-high-field magnetic resonance spectroscopy in non-alcoholic fatty liver disease: Novel mechanistic and diagnostic insights of energy metabolism in non-alcoholic steatohepatitis and advanced fibrosis.Liver international : official journal of the International Association for the Study of the Liver · 2017Article
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.Journal of proteomics · 2017Article
- Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness.Molecular imaging and biology · 2017Article
- The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression.Journal of Cancer · 2016Article
- Saponin-permeabilization is not a viable alternative to isolated mitochondria for assessing oxidative metabolism in hibernation.Biology open · 2015Article
- Article
- Low oxygen tension enhances hepatitis C virus replication.Journal of virology · 2013Article
- A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen.Investigational new drugs · 2012Article
- Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds.Mitochondrion · 2010Review
- ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function.BMC biology · 2010Article
- GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.Molecular cell · 2009Article
- Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInconsistent findings have been reported on the occurrence and relevance of creatine kinase (CK) isoenzymes in mammalian liver cells. Part of this confusion might be due to induction of CK expression during metabolic and energetic stress.
methodsThe specific activities and isoenzyme patterns of CK and adenylate kinase (AdK) were analysed in pathological liver tissue of patients undergoing orthotopic liver transplantation.
resultsThe brain-type, cytosolic BB-CK isoenzyme was detected in all liver specimens analysed. Conversely, CK activity was strongly increased and a mitochondrial CK (Mi-CK) isoenzyme was detected only in tissue samples of two primary hepatocellular carcinomas (HCCs).
conclusionThe findings do not support significant expression of CK in normal liver and most liver pathologies. Instead, many of the previous misconceptions in this field can be explained by interference from AdK isoenzymes. Moreover, the data suggest a possible interplay between p53 mutations, HCC, CK expression, and the growth-inhibitory effects of cyclocreatine in HCC. These results, if confirmed, could provide important hints at improved therapies and cures for HCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.