ArticleNutrition journal2005
The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study.
Article in Nutrition journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Targeting colorectal cancer using dietary flavonols.Cancer innovation · 2024Review
- Sex-Dependent Effects of PMInternational journal of environmental research and public health · 2019Article
- Identification of proteins with the CDw75 epitope in human colorectal cancer.Oncology letters · 2018Article
- The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation.International journal of environmental research and public health · 2017Article
- Synergism of co-delivered nanosized antioxidants displayed enhanced anticancer efficacy in human colon cancer cell lines.Bioactive materials · 2017Article
- Proteomic Analysis of Anticancer TCMs Targeted at Mitochondria.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Opportunities and challenges for nutritional proteomics in cancer prevention.The Journal of nutrition · 2012Article
- Classification of diet-modulated gene signatures at the colon cancer initiation and progression stages.Digestive diseases and sciences · 2011Article
- Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γ/IL-4 Ratio In Utero in Pregnant Mice.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer.Journal of carcinogenesis · 2007Article
- Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome.Evidence-based complementary and alternative medicine : eCAM · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh fruit and vegetable intake is known to reduce the risk of colon cancer. To improve understanding of this phenomenon the action of different phytochemicals on colon cells has been examined. One such compound is quercetin that belongs to the group known as flavonoids. The purpose of this study was to determine the influence of quercetin on the proteome of the SW480 human colon adenocarcinoma cell line, specifically to identify proteins that could be the molecular targets of quercetin in its amelioration of the progression of colon cancer. To this end, two-dimensional gel electrophoresis and mass spectrometry were used to identify proteins that underwent a change in expression following treatment of the cells with 20 muM quercetin. This could elucidate how quercetin may reduce the progression of colon cancer.
resultsQuercetin treatment of the SW480 human colon cancer cells was found to result in the decreased expression of three proteins and the increased expression of one protein. The identified proteins with decreased expression were type II cytoskeletal 8 keratin and NADH dehydrogenase Fe-S protein 3. The other protein with decreased expression was not identified. The protein with increased expression belonged to the annexin family.
conclusionSeveral proteins were determined to have altered expression following treatment with quercetin. Such changes in the levels of these particular proteins could underlie the chemo-protective action of quercetin towards colon cancer.
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