ArticleTransactions of the American Ophthalmological Society2004
Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex.
Article in Transactions of the American Ophthalmological Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 87 citations in OpenAlex.
- Tuberous sclerosis complex.Nature reviews. Disease primers · 2026Review
- Ophthalmic screening in phakomatoses.Frontiers in cell and developmental biology · 2026Article
- Advantages of optical coherence tomography in assessing retinal astrocytic hamartomas in children with tuberous sclerosis complex.Frontiers in medicine · 2026Article
- Spontaneous Regression of a Retinal Astrocytic Hamartoma in an Adolescent With Tuberous Sclerosis Complex.Cureus · 2025Article
- En face swept-source optical coherence tomography (SS-OCT) and SS-OCT angiography findings of retinal astrocytic hamartomas in patients with tuberous sclerosis complex.Frontiers in medicine · 2025Article
- Comparative study on genomic and epigenomic profiles of retinoblastoma or tuberous sclerosis complex via nanopore sequencing and a joint screening framework.Cancer gene therapy · 2024Article
- An atypical presentation of retinal astrocytic hamartoma with co-occurring SEGA in a tuberous sclerosis patient.Radiology case reports · 2024Article
- Rapid symptomatic and structural improvement of a retinal astrocytic hamartoma in response to anti-VEGF therapy: A case report.American journal of ophthalmology case reports · 2022Article
- Utility of multimodal ocular imaging in tuberous sclerosis complex-Review of literature along with a case illustration.Indian journal of ophthalmology · 2022Review
- Long-term efficacy and safety of sirolimus for retinal astrocytic hamartoma associated with tuberous sclerosis complex.Frontiers in cell and developmental biology · 2022Article
- Congenital focal abnormalities of the retina and retinal pigment epithelium.Eye (London, England) · 2020Review
- Optic nerve head reactive retinal astrocytic tumor treated with photodynamic therapy.American journal of ophthalmology case reports · 2020Article
- Clinical features and optical coherence tomography findings of retinal astrocytic hamartomas in Chinese patients with tuberous sclerosis complex.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Retinal anaplastic pleomorphic xanthoastrocytoma unassociated with phakomatosis.Journal of current ophthalmology · 2019Article
- Neuro-ophthalmological manifestations of tuberous sclerosis: current perspectives.Eye and brain · 2019Article
- Retinal astrocytic hamartoma in tuberous sclerosis complex in an elderly person: a case report.BMC ophthalmology · 2018Article
- Tuberous sclerosis complex: a clinical case with multiple ophthalmological manifestations.BMJ case reports · 2018Article
- Chronic papilledema in a child with classical tuberous sclerosis.Indian journal of ophthalmology · 2018Article
- Macular telangiectasia type 2 accompanied by solitary retinal astrocytic hamartoma (case report).BMC ophthalmology · 2016Article
- A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development.Disease models & mechanisms · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo report the clinical and histopathologic findings of retinal astrocytic tumors that showed progressive growth in four patients with tuberous sclerosis complex (TSC).
methodsFour young children each developed an enlarging retinal neoplasm that eventually necessitated enucleation of the affected eye. The systemic findings, clinical course, and histopathologic findings were reviewed.
resultsEach patient had a progressively enlarging retinal mass associated with a total exudative retinal detachment and neovascular glaucoma. Enucleation was necessary in each case because the affected eye became blind and painful. The mean patient age at enucleation was 7 years, and the median age was 3 years. At the time of enucleation the tumors ranged from 10 to 20 mm in basal diameter and from 10 to 25 mm in thickness. Histopathologic studies of each eye revealed a giant cell astrocytoma that had produced a total exudative retinal detachment. The tumor cells showed positive immunoreactivity to neuron-specific enolase and glial fibrillary acidic protein. The retinal neoplasms in these cases were identical histopathologically to the subependymal giant cell astrocytoma that typifies TSC in the brain. One tumor filled the entire eye and perforated the globe. Although the lesions simulated retinoblastoma clinically, each patient had ocular and systemic findings of TSC, supporting the diagnosis of astrocytic hamartoma.
conclusionsAlthough retinal astrocytic lesions of TSC generally are stationary, they can sometimes grow relentlessly and cause severe ocular complications. Patients with retinal astrocytic hamartomas should have serial ophthalmic evaluations because of this possibility.
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15747752PMC1280094W19534578What OpenQuestion holds
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