ArticleThe Journal of infectious diseases2005
In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins.
Article in The Journal of infectious diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 107 citations in OpenAlex.
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- Extracellular Proteomic Profiling from the Erythrocytes Infected with Plasmodium Falciparum 3D7 Holds Promise for the Detection of Biomarkers.The protein journal · 2024Article
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- Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles.PLoS neglected tropical diseases · 2023Article
- Determination of the Stage Composition ofmSystems · 2022Article
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- Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity?PLoS pathogens · 2021Review
- Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofFrontiers in cellular and infection microbiology · 2021Article
- The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background.Nature communications · 2018Article
- Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Plasmodium knowlesi: a superb in vivo nonhuman primate model of antigenic variation in malaria.Parasitology · 2018Review
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- Plasmodium Helical Interspersed Subtelomeric (PHIST) Proteins, at the Center of Host Cell Remodeling.Microbiology and molecular biology reviews : MMBR · 2016Review
- Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the way.Wiley interdisciplinary reviews. RNA · 2016Review
- Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton.Cellular microbiology · 2016Article
- Plasmodium falciparum gene expression measured directly from tissue during human infection.Genome medicine · 2014Article
- Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers.PloS one · 2014Article
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- Comparative Genomics and Systems Biology of Malaria ParasitesCurrent bioinformatics · 2012Article
- A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Infections with the human parasite Plasmodium falciparum continue to present a great challenge to global health. Fundamental questions regarding the molecular basis of virulence and immune evasion in P. falciparum have been only partially answered. Because of the parasite's intracellular location and complex life cycle, standard genetic approaches to the study of the pathogenesis of malaria have been limited. The present study presents a novel approach to the identification of the biological processes involved in host-pathogen interactions, one that is based on the analysis of in vivo P. falciparum transcripts. We demonstrate that a sufficient quantity of P. falciparum RNA transcripts can be derived from a small blood sample from infected patients for whole-genome microarray analysis. Overall, excellent correlation was observed between the transcriptomes derived from in vivo samples and in vitro samples with ring-stage P. falciparum 3D7 reference strain. However, gene families that encode surface proteins are overexpressed in vivo. Moreover, this analysis has identified a new family of hypothetical genes that may encode surface variant antigens. Comparative studies of the transcriptomes derived from in vivo samples and in vitro 3D7 samples may identify important strategies used by the pathogen for survival in the human host and highlight, for vaccine development, new candidate antigens that were not previously identified through the use of in vitro cultures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.