Evidence map›Paper›PMID 15746367›Full record

ArticleApplied and environmental microbiology2005

Genomic comparisons of Salmonella enterica serovar Dublin, Agona, and Typhimurium strains recently isolated from milk filters and bovine samples from Ireland, using a Salmonella microarray.

F J Reen, E F Boyd, S Porwollik, B P Murphy, D Gilroy, S Fanning, M McClelland

Open access · greenAbstract readComparative Study
In one paragraph

Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 60 citations in OpenAlex.

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  10. Novel genetic tools for studying food-borne Salmonella.Current opinion in biotechnology · 2009
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

F J ReenDepartment of Microbiology, University College Cork, National University of Ireland-Cork, Cork, Ireland.
E F Boyd
S Porwollik
B P Murphy
D Gilroy
S Fanning
M McClelland
Munster Technological University · IESidney Kimmel Cancer Center · USNational University of Ireland · IEUniversity College Cork · IEUniversity College Dublin · IE

Funding

SALMONELLA GENES REQUIRED FOR SURVIVAL IN THE MACROPHAGER01AI022933 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI HEFFRON, FRED L · 1987 to 2013
$4.6M
Comparative Genomics in the EnterobateriaceaeR01AI052237 · NIAID · WASHINGTON UNIVERSITY · PI WEINSTOCK, GEORGE M · 2002 to 2009
$4.1M
DETAILED RESTRICTION MAP--SALMONELLA TYPHIMURIUM GENOMER01AI034829 · NIAID · SIDNEY KIMMEL CANCER CENTER · PI MCCLELLAND, MICHAEL · 1993 to 2006
$1.9M
NIAID NIH HHS R01 AI022933NIAID NIH HHS R01AI022933NIAID NIH HHS R01 AI034829NIAID NIH HHS R01 AI052237NIAID NIH HHS R01AI34829NIAID NIH HHS R01AI52237
6 · The paper itself

Abstract

Salmonella-induced enterocolitis is the leading food-borne illness with a lethal outcome and causes millions of cases of gastroenteritis each year. We examined genomic variation among 12 environmental, veterinary, and clinical Salmonella enterica serovar Dublin, Agona, and Typhimurium strains isolated in Ireland between 2000 and 2003, as well as two clinical isolates from Canada and four archival isolates, which belonged to serovars Dublin and Agona. Using DNA-DNA hybridization to a microarray consisting of most of the predicted protein-encoding sequences of the S. enterica serovar Typhimurium LT2 genome, we identified a number of genomic regions that were absent in one or more serovars. The 34 genomic regions encoded proteins involved in sugar metabolism, transport, fimbrial and phage biogenesis, and transcriptional regulation, as well as inner and outer membrane-associated proteins. Two of the four prophages identified in strain LT2, prophages Gifsy-1 and Gifsy-2, were present in all six serovar Typhimurium strains examined. Prophage Fels-1 was absent from all 18 isolates examined, and Fels-2 was completely absent from the serovar Typhimurium isolates and the Salmonella Reference Collection B serovar Dublin strain Du2. All five Salmonella pathogenicity islands were present in all isolates. Plasmid pSLT was absent from all serovar Agona isolates, and only homologues of the spv genes were present in eight of the nine serovar Dublin strains. Only limited intraserovar diversity was found among the nine serovar Dublin, three serovar Agona, and six serovar Typhimurium isolates examined even though these isolates had extensive geographic, temporal, and source differences.

Indexed as

AnimalsCattleDNA, BacterialFemaleFiltrationFood MicrobiologyGenetic VariationGenome, BacterialHumansIrelandMilkOligonucleotide Array Sequence AnalysisPlasmidsProphagesRNA, BacterialRNA, TransferDNA, BacterialRNA, BacterialRNA, Transfer

Identifiers

PMID15746367
PMCPMC1065154
OpenAlexW1974985820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.