ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Neural substrates for behaviorally conditioned immunosuppression in the rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 95 citations in OpenAlex.
- Sustained learned immunosuppression could not prevent local allergic ear swelling in a rat model of contact hypersensitivity.Scientific reports · 2025Article
- Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- The psychological costs of behavioral immunity following COVID-19 diagnosis.Scientific reports · 2024Article
- Neuroplasticity Intervention, Amygdala and Insula Retraining (AIR), Significantly Improves Overall Health and Functioning Across Various Chronic Conditions.Integrative medicine (Encinitas, Calif.) · 2023Article
- Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission.Molecular psychiatry · 2022Article
- The Potential Mechanisms of High-Velocity, Low-Amplitude, Controlled Vertebral Thrusts on Neuroimmune Function: A Narrative Review.Medicina (Kaunas, Lithuania) · 2021Review
- Inflammation neuroscience: neuro-immune crosstalk and interfaces.Clinical & translational immunology · 2021Review
- Neuronal regulation of immunity: why, how and where?Nature reviews. Immunology · 2021Review
- Learned immunosuppressive placebo responses in renal transplant patients.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Interleukin-1 signaling in the basolateral amygdala is necessary for heroin-conditioned immunosuppression.Brain, behavior, and immunity · 2017Article
- Neural regulation of immunity: molecular mechanisms and clinical translation.Nature neuroscience · 2017Review
- Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus.Brain, behavior, and immunity · 2016Article
- The neural correlates of volitional attention: A combined fMRI and ERP study.Human brain mapping · 2015Article
- The neuroscience of placebo effects: connecting context, learning and health.Nature reviews. Neuroscience · 2015Review
- Integrated neurobiology of bipolar disorder.Frontiers in psychiatry · 2014Review
- Review
- Placebo and the new physiology of the doctor-patient relationship.Physiological reviews · 2013Review
- Learned immunosuppression: extinction, renewal, and the challenge of reconsolidation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Placebo effects on the immune response in humans: the role of learning and expectation.PloS one · 2012Article
- Brain-immune interactions and the neural basis of disease-avoidant ingestive behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated behaviorally conditioned immunosuppression using cyclosporin A as an unconditioned stimulus and saccharin as a conditioned stimulus. In the current study, we examined the central processing of this phenomenon generating excitotoxic lesions before and after acquisition to discriminate between learning and memory processes. Three different brain areas were analyzed: insular cortex (IC), amygdala (Am), and ventromedial nucleus of the hypothalamus (VMH). The results demonstrate that IC lesions performed before and after acquisition disrupted the behavioral component of the conditioned response (taste aversion). In contrast, Am and VMH lesions did not affect conditioned taste aversion. The behaviorally conditioned suppression of splenocyte proliferation and cytokine production (interleukin-2 and interferon-gamma) was differentially affected by the excitotoxic lesions, showing that the IC is essential to acquire and evoke this conditioned response of the immune system. In contrast, the Am seems to mediate the input of visceral information necessary at the acquisition time, whereas the VMH appears to participate within the output pathway to the immune system necessary to evoke the behavioral conditioned immune response. The present data reveal relevant neural mechanisms underlying the learning and memory processes of behaviorally conditioned immunosuppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.