ArticleDigestive diseases and sciences2005
Is there anything to the reported association between Helicobacter pylori infection and autoimmune thyroiditis?
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Association between Helicobacter pylori infection and thyroid dysfunction in adults visiting a tertiary care hospital in Karachi, Pakistan: a cross-sectional study.BMC endocrine disorders · 2026Article
- Association betweenFrontiers in endocrinology · 2025Article
- Correlation between Autoimmune Hashimoto's Thyroiditis andMiddle East journal of digestive diseases · 2024Article
- Association ofJournal of clinical medicine · 2023Article
- Association betweenFrontiers in endocrinology · 2022Article
- Association between thyroid autoimmunity andThe Korean journal of internal medicine · 2017Article
- Molecular mimicry and autoimmune thyroid disease.Reviews in endocrine & metabolic disorders · 2016Review
- Helicobacter pylori infection in women with Hashimoto thyroiditis: A case-control study.Medicine · 2016Article
- Helicobacter pylori and autoimmune disease: cause or bystander.World journal of gastroenterology · 2014Review
- Autoimmune thyroid diseases and Helicobacter pylori: the correlation is present only in Graves's disease.World journal of gastroenterology · 2012Article
- Helicobacter pylori infection might be responsible for the interconnection between type 1 diabetes and autoimmune thyroiditis.Diabetology & metabolic syndrome · 2011Article
- Cure of alopecia areata after eradication of Helicobacter pylori: a new association?World journal of gastroenterology · 2011Article
- Helicobacter pylori infection and endocrine disorders: is there a link?World journal of gastroenterology · 2009Review
- Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta-analytic, and experimental evidence.World journal of gastroenterology · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher serological prevalence rates of Helicobacter pylori (Hp) infection have been reported in patients with autoimmune thyroiditis (AT), and it has been suggested that monoclonal antibodies against Cag-A positive Hp strains can cross-react with follicular cells of the thyroid gland. We studied the prevalence of AT and thyroid functional status in patients who underwent gastroscopy for dyspeptic symptoms. Patients were tested for TSH, free thyroid hormones, and antithyroglobulin and antithyroperoxidase antibodies (ATPO). Hp positivity was determined using urea breath test (UBT). Serum samples from 302 patients (59.9% women) were evaluated. One hundred ninety-one subjects (63.2%) were Hp-negative, and 111 of 302 (36.8%) were Hp-positive. Forty-three of 191 Hp-negative patients (22.5%; 95% CI, 17.1-29.0%) had an increase of either antibody, compared to 30 of 111 (27.0%; 95% CI, 19.6-36.0%) Hp-positive patients (P = 0.40). Similar results were obtained using positivity for both antibodies (7.3 vs. 7.2%; P = 1) or for ATPO (18.8 vs. 21.6%; P = 0.54). The prevalences of hypothyroidism (4.7 vs. 5.5%) or hyperthyroidism (5.8 vs. 5.5%) were also similar (P = 0.95). Hormonal levels were not different in the two groups (P > 0.22 in all cases). The previously reported association between AT and Hp infection was not observed in our study. Infection by Hp does not appear to increase the risk of AT in individuals with dyspeptic symptoms, and screening for this condition in patients with a positive UBT is not indicated.
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