ArticleDigestive diseases and sciences2005
Genotypic and phenotypic stability of Helicobacter pylori markers in a nine-year follow-up study of patients with noneradicated infection.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Genomic characterization of a Helicobacter pylori isolate from a patient with gastric cancer in China.Gut pathogens · 2014Article
- Genomes of two chronological isolates (Helicobacter pylori 2017 and 2018) of the West African Helicobacter pylori strain 908 obtained from a single patient.Journal of bacteriology · 2011Article
- Microevolution of Helicobacter pylori type IV secretion systems in an ulcer disease patient over a ten-year period.Journal of clinical microbiology · 2007Article
- An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Pathogen evolution in vivo: genome dynamics of two isolates obtained 9 years apart from a duodenal ulcer patient infected with a single Helicobacter pylori strain.Journal of clinical microbiology · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The cagA gene, alleles of the vacA gene,random amplified polymorphic DNA (RAPD), and neutrophil activating capacity (HpNAC) were used to examine paired H. pylori isolates from 10 noneradicated individuals 9 years apart. Paired isolates from each patient were indistinguishable with regard to vacA alleles, RAPD, and HpNAC. Isolates from nine patients showed concordance for the cagA gene, which was not detected in the recent isolate of the tenth patient. Antibodies to CagA were, however, demonstrated in the serum specimens 9 years apart and were also present in two other patients whose paired isolates were cagA-, indicating the existence of both cagA+ and cagA-organisms, with the latter predominating in some patients. The present study suggests a greater stability of phenotypic and genotypic markers of H. pylori than previously regarded. This might be true for a community with low infection and transmission rates. Complementary techniques like microarrays might, however, disclose evolutionary changes not identified here.
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