ArticleDigestive diseases and sciences2005
Risk factors for thromboembolic complications in inflammatory bowel disease: the role of hyperhomocysteinaemia.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Factor V Leiden and inflammatory bowel disease: a systematic review and meta-analysis.Journal of gastroenterology · 2011Pooled it
- Effects of Aerobic Treadmill Training on Oxidative Stress Parameters, Metabolic Enzymes, and Histomorphometric Changes in Colon of Rats with Experimentally Induced Hyperhomocysteinemia.International journal of molecular sciences · 2024Article
- Acute pulmonary embolism following corticosteroid administration in acute severe ulcerative colitis with gastrointestinal bleeding: A case report.Frontiers in cardiovascular medicine · 2022Article
- International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2021Article
- Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis.Mediators of inflammation · 2021Article
- Cerebral venous thrombosis in a child with inflammatory bowel disease.Iranian journal of child neurology · 2021Article
- Budd-Chiari syndrome: a rare and life-threatening complication of Crohn's disease.BMJ case reports · 2018Article
- From Pulmonary Embolism to Inflammatory Bowel Disease; Give Tunnel Vision up.Emergency (Tehran, Iran) · 2016Article
- Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn's disease.World journal of gastroenterology · 2015Article
- Cardiovascular complications in inflammatory bowel disease.Current drug targets · 2015Review
- Neurological disorders and inflammatory bowel diseases.World journal of gastroenterology · 2014Review
- Venous thrombosis and prothrombotic factors in inflammatory bowel disease.World journal of gastroenterology · 2014Review
- Venous thromboembolism in patients with inflammatory bowel disease: focus on prevention and treatment.World journal of gastroenterology · 2014Review
- [Neurological complications of inflammatory bowel diseases].Der Nervenarzt · 2013Review
- Catheter-directed thrombolysis in inflammatory bowel diseases: report of a case.World journal of gastroenterology · 2012Article
- B-vitamin deficiency is protective against DSS-induced colitis in mice.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Comorbidity in inflammatory bowel disease.World journal of gastroenterology · 2011Review
- Haemostatic system in inflammatory bowel diseases: new players in gut inflammation.World journal of gastroenterology · 2011Review
- Thrombophilic Risk Factors in Patients With Inflammatory Bowel Disease.Gastroenterology research · 2010Article
- Assessment of thrombophilic abnormalities during the active state of inflammatory bowel disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) is associated with an increased risk for thromboembolic events. Aim of this study was to examine the relationship of hyperhomocysteinemia and thrombosis in IBD patients and to assess the role of this factor in addition to other known prothrombotic abnormalities. IBD patients with a history of thrombosis (n = 22) and sex-, age-, and diagnosis-matched IBD controls (n = 23) were studied. Homocysteine (tHcy) was assessed before and after methionine loading. Plasma levels of protein C, protein S, antithrombin III, and fibrinogen and the presence of anticardiolipin and antiphospholipid antibodies were determined and genetic testing for factor V Leiden and the prothrombin gene mutation was performed. Results showed that fasting homocysteine levels in IBD patients with a history of arterial or venous thrombosis tended to be higher than in IBD controls, although not significantly. The increase in homocysteine levels after methionine loading was significantly higher in IBD patients in the arterial thrombosis group than in IBD controls (40.9 +/- 17.7 vs. 27.2 +/- 9.9 microM; P < 0.05). Among the other prothrombotic factors, only factor V Leiden was significantly associated with a history of venous thrombosis (20 vs. 0%). At least one risk factor was found in 64% of the IBD patients with previous thromboembolic complications. We conclude that there is an association between hyperhomocysteinemia and a history of arterial thrombosis in IBD patients. We confirm the high prevalence of factor V Leiden in IBD patients with a history of venous thrombosis. In the majority of IBD patients with previous thromboembolic complications, at least one prothrombotic risk factor is detected.
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